DAB1
Reactivity: Human, Mouse, Rat
WB, ELISA, IF
Host: Rabbit
Polyclonal
unconjugated
Application Notes
Western Blot: 1 - 5 μg/mL. Immunoprecipitation: 5 - 10 μg/mL. Positive Control: 293 cells transfected with Dab-1 HA tag. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Buffer
PBS, 0.08 % Sodium Azide
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
-20 °C
Storage Comment
The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.
Disruption of the disabled-1 gene (Dab1) results in aberrant migration of neurons during development and disorganization of laminar structures throughout the brain. Dab1 is thought to function as an adaptor molecule in signal transduction processes. It contains a protein-protein interaction (PI) similar to the phosphotyrosine binding domain of the Shc oncoprotein, it is phosphorylated by the Src protein tyrosine kinase, and it binds to SH2 binding domains in a phosphotyrosine dependent manner. Disabled-1 acts downstream of reelin in a signalling pathway.Synonyms: Disabled homolog 1