DAB1 antibody (C-Term)

Catalog No. ABIN264970

This Sheep Polyclonal antibody specifically detects DAB1 in WB and IP. It exhibits reactivity toward Mouse.

Quick Overview for DAB1 antibody (C-Term) (ABIN264970)

Target: DAB1 (Disabled Homolog 1 (Drosophila) (DAB1))

Reactivity: Mouse

Host: Sheep

Clonality: Polyclonal

Conjugate: This DAB1 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-DAB1 Antibody

Binding Specificity: C-Term

Specificity: This antibody reacts to DAB1 (Disabled 1) (C Terminal).

Purification: Purified

Immunogen: Recombinant protein corresponding to amino acids 399 - 555 of mouse disabled coupled to a GST fusion protein.

Isotype: IgG

Application Details

Application Notes: Western Blot: 1 μg/mL. Immunoprecipitation: 5 μg/mL. POSITIVE CONTROL: 293 cells transfected with Dab-1-HA tag.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

Target Details for DAB1

Target: DAB1 (Disabled Homolog 1 (Drosophila) (DAB1))

Alternative Name: DAB1

Background: Disruption of the disabled-1 gene (Dab1) results in aberrant migration of neurons during development and disorganization of laminar structures throughout the brain. Dab1 is thought to function as an adaptor molecule in signal transduction processes. It contains a protein-protein interaction (PI) similar to the phosphotyrosine binding domain of the Shc oncoprotein, it is phosphorylated by the Src protein tyrosine kinase, and it binds to SH2 binding domains in a phosphotyrosine dependent manner. Disabled-1 acts downstream of reelin in a signalling pathway.Synonyms: Disabled homolog 1

Gene ID: 13131

NCBI Accession: NP_034144

UniProt: P97318