SLAMF1 antibody (APC)

Catalog No. ABIN2658851

Product Details anti-SLAMF1 Antibody (APC)

Target: SLAMF1 (Signaling Lymphocytic Activation Molecule Family Member 1 (SLAMF1))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This SLAMF1 antibody is conjugated to APC

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), Blocking Reagent (BR)

Purification: The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.

Clone: TC15-12F12-2

Isotype: IgG2a lambda

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.2 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from prolonged exposure to light. Do not freeze.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for SLAMF1

Target: SLAMF1 (Signaling Lymphocytic Activation Molecule Family Member 1 (SLAMF1))

Alternative Name: CD150 (SLAMF1 Products)

Synonyms: CD150 antibody, SLAM antibody, SLAMF1 antibody, 4933415F16 antibody, AA177906 antibody, CDw150 antibody, ESTM51 antibody, IPO-3 antibody, Slam antibody, RGD1560634 antibody, signaling lymphocytic activation molecule family member 1 antibody, SLAMF1 antibody, Slamf1 antibody

Background: CD150 is a 75-95 kD member of the immunoglobulin superfamily, also known as SLAM (signaling lymphocyte activation molecule) or IPO-3. CD150, a single chain type I transmembrane molecule, is expressed on thymocytes, T cell subsets, B cells, dendritic cells, and endothelial cells. The expression is upregulated upon activation. CD150 expression has been shown to be maintained on Th1 but not Th2 clones. T regulatory cells express a relatively high level of CD150. Antibodies against CD150 have been shown to augment IFN-γ production by Th1 cells, especially when co-stimulated through the TCR. CD150 associates with the src homology 2-domain-containing protein tyrosine phosphatase SHP-2, and this association is thought to be involved in signal transduction. In combination with CD48, CD150 is a useful marker for hematopoietic stem cell studies.