DLL4 antibody (PE)

Catalog No. ABIN2663679

The PE-conjugated Hamster Monoclonal anti-DLL4 antibody (Clone HMD4-1) (ABIN2663679) specifically detects DLL4 in WB and IHC. The antibody is reactive with Mouse samples.

Quick Overview for DLL4 antibody (PE) (ABIN2663679)

Target: DLL4 (delta-Like 4 (DLL4))

Reactivity: Mouse

Host: Hamster

Clonality: Monoclonal

Conjugate: This DLL4 antibody is conjugated to PE

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: HMD4-1

Product Details anti-DLL4 Antibody (PE)

Purification: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.2 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from prolonged exposure to light. Do not freeze.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for DLL4

Target: DLL4 (delta-Like 4 (DLL4))

Alternative Name: delta-Like 4

Background: The Notch receptors and their ligands are highly conserved from invertebrates to mammals. Delta-like 4 (DLL4) is one of four or five Notch ligands identified. The binding to Notch receptor results in the proteolysis of Notch and movement of intracellular portions of Notch into the nucleus. This translocation triggers a series of signaling processes. DLL4 is reported to be essential for the regulation of angiogenesis. In thymus, DLL4 is an essential Notch1 ligand responsible for T cell lineage commitment.

Pathways: Notch Signaling