Caspase 1 antibody

Catalog No. ABIN2664090

This Rat Monoclonal antibody specifically detects Caspase 1 in FACS. It exhibits reactivity toward Mouse.

Quick Overview for Caspase 1 antibody (ABIN2664090)

Target: Caspase 1 (CASP1)

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This Caspase 1 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Clone: 5B10

Product Details anti-Caspase 1 Antibody

Purification: The antibody was purified by affinity chromatography.

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for Caspase 1

Target: Caspase 1 (CASP1)

Alternative Name: Caspase-1

Background: Caspase -1 plays a vital role in cleaving the inactive procytokine pro-IL-1 beta to generate the active 17 kd mature form of IL-1beta, a key mediator of inflammation. Active caspase-1 (ICE) is derived a single proenzyme of 45 Kd. An active ICE comprises two subunits of P20 and two subunits of P10 after removal a large amino-terminal pro-domain and a small linker peptide. Caspase-1 is reported to be involved in CD95- mediated apoptosis. Four alternatively spliced variants of caspase-1 have been reported, with mw ranging from 30-48 kd.

Pathways: Apoptosis, Interferon-gamma Pathway, Positive Regulation of Endopeptidase Activity, Inflammasome