IL4 Receptor antibody (Interleukin 4 Receptor)

Details for Product anti-IL4R Antibody No. ABIN2664185, Supplier: Log in to see
Antigen
  • IL4R
  • il-4ra
  • zgc:113063
  • CD124
  • IL-4RA
  • IL4RA
  • Il4ra
  • IL4
  • Il4r
  • interleukin 4 receptor
  • interleukin 4 receptor, tandem duplicate 1
  • interleukin 4 receptor, alpha
  • IL4R
  • il4r.1
  • Il4r
  • Il4ra
Alternatives
anti-Human IL4 Receptor antibody for Enzyme Immunoassay
Reactivity
Mouse (Murine)
108
50
11
Host
Rat
72
47
12
10
1
Clonality (Clone)
Monoclonal ()
Conjugate
This IL4 Receptor antibody is un-conjugated
9
8
4
2
1
1
1
1
1
1
1
1
1
1
Application
ELISA (Detection), ELISpot (Detection) (ELISPOT (Detection)), Intracellular Flow Cytometry (ICFC)
78
63
42
23
15
10
10
10
7
5
4
3
3
2
2
2
1
1
1
Options
Supplier
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Supplier Product No.
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Clone I015F8
Isotype IgG2b kappa
Purification The antibody was purified by affinity chromatography.
Plasmids, Primers & others Plasmids, Primers & others IL4 Receptor products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name CD124 (IL4R Antibody Abstract)
Background CD124, a subunit of IL-4R, is a 140 kD transmembrane glycoprotein. It associates with either the common γ-chain (CD132) to form the type I IL-4R complex, which specifically binds IL-4, or with IL-13Ra1 to form the type II IL-4R heterodimeric complex, which binds and transduces signals from either IL-4 or IL-13. A truncated form of IL-4Rα exists in soluble form in biological fluids. CD124 is expressed on mouse late precursors and mature B cells, T cells, monocytes, and has low expression on granulocytes. In B cells, CD124 can bind IL-4 and IL-13 and regulate IgE antibody production. In T cells, the type I IL-4R (IL-4R/gC) is mostly responsible for Th2 cell expansion by mediating IL-4-dependent activation of the transcription factors in hematopoietic cells. The type II IL-4R (IL-4R/IL-13Ra1) is the main route for nonhematopoietic cell responses to IL-4 or IL-13.
Pathways JAK-STAT Signaling, Positive Regulation of Immune Effector Process
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.
Supplier Images
Flow Cytometry (FACS) image for anti-Interleukin 4 Receptor (IL4R) antibody (ABIN2664185) anti-Interleukin 4 Receptor (IL4R) antibody
Flow Cytometry (FACS) image for anti-Interleukin 4 Receptor (IL4R) antibody (ABIN2664185) anti-Interleukin 4 Receptor (IL4R) antibody (Image 2)
Background publications Gilmour, Lavender: "Control of IL-4 expression in T helper 1 and 2 cells." in: Immunology, Vol. 124, Issue 4, pp. 437-44, 2008 (PubMed).

Kashiwada, Giallourakis, Pan, Rothman: "Immunoreceptor tyrosine-based inhibitory motif of the IL-4 receptor associates with SH2-containing phosphatases and regulates IL-4-induced proliferation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 11, pp. 6382-7, 2001 (PubMed).

Hage, Sebald, Reinemer: "Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface." in: Cell, Vol. 97, Issue 2, pp. 271-81, 1999 (PubMed).

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