TICAM1 antibody

Catalog No. ABIN2665411

The Mouse Monoclonal anti-TICAM1 antibody is suitable to detect TICAM1 in samples from Human and Mouse. It has been validated for FACS.

Quick Overview for TICAM1 antibody (ABIN2665411)

Target: TICAM1 (Toll-Like Receptor Adaptor Molecule 1 (TICAM1))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This TICAM1 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Clone: 1H4B01

Product Details anti-TICAM1 Antibody

Purification: The antibody was purified by affinity chromatography.

Isotype: IgG2a kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for TICAM1

Target: TICAM1 (Toll-Like Receptor Adaptor Molecule 1 (TICAM1))

Alternative Name: TICAM-1

Background: TICAM-1, also known as TRIF, is an intracellular adaptor protein utilized by TLR3 and TLR4. TLR3 recognizes double stranded viral RNA and induces TICAM-1 mediated type I interferon production. The N-terminal region of TICAM-1 recruits TBK1 and IKKi, which in turn phosphorylates the interferon regulatory transcription factor IRF3. The phosphorylated IRF3 is subsequently dimerized and translocates to the nucleus, resulting in transcriptional activation of the gene encoding IFN-β. Mice lacking in TICAM-1 expression are defective in the TLR3 mediated induction of proinflamatory cytokines, suggesting that TICAM-1 is crucial for TLR3 downstream signaling. TICAM-1 also mediates TLR4-induced signaling in the presence of the adaptor molecule TRAM. The C-terminal region of TICAM-1 recruits RIP1 and induces apoptosis through FADD/caspase cascade.

Pathways: TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades