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- Target See all IRF7 Antibodies
- IRF7 (Interferon Regulatory Factor 7 (IRF7))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This IRF7 antibody is un-conjugated
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Application
- Biochemical Assay (BCA)
- Purification
- Affinity purified
- Clone
- 12G9A36
- Isotype
- IgG2b kappa
- Top Product
- Discover our top product IRF7 Primary Antibody
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anti-Interferon Regulatory Factor 7 (IRF7) (pSer471), (pSer472) antibody
IRF7 Reactivity: Human, Mouse, Rat WB, ELISA, FACS, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-Interferon Regulatory Factor 7 (IRF7) (AA 401-503) antibodyIRF7 Reactivity: Human, Mouse, Rat, Pig WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-Interferon Regulatory Factor 7 (IRF7) (AA 131-289) antibodyIRF7 Reactivity: Human ELISA, IHC, IF Host: Rabbit Polyclonal unconjugated
anti-Interferon Regulatory Factor 7 (IRF7) (AA 1-150), (N-Term) antibodyIRF7 Reactivity: Human WB, IHC (p), EIA Host: Mouse Monoclonal 3D9 unconjugated
anti-Interferon Regulatory Factor 7 (IRF7) antibodyIRF7 Reactivity: Human WB, IF (cc) Host: Rabbit Monoclonal 2A1 unconjugated
anti-Interferon Regulatory Factor 7 (IRF7) (AA 257-516) antibodyIRF7 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
anti-Interferon Regulatory Factor 7 (IRF7) (C-Term) antibodyIRF7 Reactivity: Human, Mouse, Rat WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
anti-Interferon Regulatory Factor 7 (IRF7) (AA 35-84) antibodyIRF7 Reactivity: Human, Mouse, Rat, Horse WB Host: Rabbit Polyclonal unconjugated
anti-Interferon Regulatory Factor 7 (IRF7) (N-Term) antibodyIRF7 Reactivity: Human, Mouse, Rat, Pig, Zebrafish (Danio rerio), Horse, Rabbit, Cow WB Host: Rabbit Polyclonal unconjugated
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Storage Comment
- Upon receipt, store undiluted between 2°C and 8°C.
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- Target
- IRF7 (Interferon Regulatory Factor 7 (IRF7))
- Alternative Name
- IRF7 (IRF7 Products)
- Synonyms
- wu:fl24c03 antibody, zgc:66043 antibody, zgc:77947 antibody, IRF7 antibody, irf7 antibody, IRF-7H antibody, IRF7A antibody, IRF7B antibody, IRF7C antibody, IRF7H antibody, interferon regulatory factor 7 antibody, irf7 antibody, IRF7 antibody, Irf7 antibody
- Background
- IRF-7 is a member of the interferon regulatory transcription factor family that plays key regulatory roles in innate immunity. Upon virus infection, IRF-7 forms a complex with MyD88 and TRAF6 when stimulated by toll-like receptors TLR7, TLR8, and TLR9, which in turn results in nuclear translocation and induction of interferon gene expression. IRF-7 gene expression is upregulated by the stimulation of interferon through the Jak-STAT signaling pathway, which forms a positive feedback loop. The protein level of IRF-7 after activation is then downregulated by the ubiquitin-proteasome system to avoid excessive production of interferons that may cause damage to the host. Virus induced type I interferon expression was completely abrogated in IRF-7 knockout mice, suggesting that IRF-7 is critical for interferon mediated host defense during virus infection.
- Pathways
- TLR Signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, Autophagy
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