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RAG2 antibody
RAG2
Reactivity: Human, Mouse
WB
Host: Mouse
Monoclonal
3G4A26
unconjugated
Product Details anti-RAG2 Antibody
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Target
See all RAG2 Antibodies
RAG2
(Recombination Activating Gene 2 (RAG2))
Reactivity
All reactivities for RAG2 antibodies
Human, Mouse
Host
All hosts for RAG2 antibodies
Mouse
Clonality
All clonalities for RAG2 antibodies
Monoclonal
Conjugate
All conjugates for RAG2 antibodies
This RAG2 antibody is un-conjugated
Application
All applications for RAG2 antibodies
Western Blotting (WB)
Purification
Affinity purified.
Clone
3G4A26
Isotype
IgG2b kappa
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Concentration
0.5 mg/mL
Buffer
phosphate-buffered solution, pH 7.2, containing 0.05 % sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C
Storage Comment
Upon receipt, store undiluted between 2°C and 8°C.
Target Details for RAG2
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Target
RAG2
(Recombination Activating Gene 2 (RAG2))
Alternative Name
RAG2 (RAG2 Products )
Synonyms
RAG-2 antibody, Rag-2 antibody, rag-2 antibody, zgc:136743 antibody, recombination activating 2 antibody, recombination activating gene 2 antibody, recombination activating gene 2 S homeolog antibody, RAG2 antibody, Rag2 antibody, rag2 antibody, rag2.S antibody
Background
During T cell and B cell development, RAG2 works together with RAG1 to induce DNA rearrangement and assembly of antigen receptor coding segments. Defects in RAG2 gene lead to the complete lack of mature T and B lymphocytes and result in severe combined immunodeficiency (SCID). RAG2 also functions in chromosome binding through its unique plant homeodomain (PHD). Sequestration of recombination signal sequences (RSS) within the nucleosome by RAG2 prevents access by the recombinase complex.
Pathways
Chromatin Binding , Production of Molecular Mediator of Immune Response
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