BID antibody

Catalog No. ABIN2666317

The Rat Monoclonal anti-BID antibody has been validated for FACS. It is suitable to detect BID in samples from Human.

Quick Overview for BID antibody (ABIN2666317)

Target: BID (BH3 Interacting Domain Death Agonist (BID))

Reactivity: Human

Host: Rat

Clonality: Monoclonal

Conjugate: This BID antibody is un-conjugated

Application: Flow Cytometry (FACS)

Clone: 1H11

Product Details anti-BID Antibody

Purification: The antibody was purified by affinity chromatography.

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: phosphate-buffered solution, pH 7.2, 0.09 % Sodium azide.

Storage: 4 °C

Storage Comment: Upon receipt, store undiluted between 2°C and 8°C.

Target Details for BID

Target: BID (BH3 Interacting Domain Death Agonist (BID))

Alternative Name: BID

Background: BID, a BH3 interacting domain death agonist is a member of the Bcl-2/Bcl-xL family. BID can form a heterodimer with either agonist BAX or antagonist Bcl-2. It is a mediator of mitochondrial damage induced by Caspase-8 (CASP8). After the cleavage by CASP8, the COOH-terminal part translocates to mitochondria and induces cytochrome c release, which in turn activates downstream caspases. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined.

Pathways: Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity