Retinoic Acid Receptor beta antibody (AA 413-448)

Catalog No. ABIN2668691

Cited in 2+ publications. The Mouse Monoclonal anti-Retinoic Acid Receptor beta antibody (Clone 8B-10B2) (ABIN2668691) specifically detects Retinoic Acid Receptor beta in WB, IHC and SSA. The antibody is reactive with Human samples.

Quick Overview for Retinoic Acid Receptor beta antibody (AA 413-448) (ABIN2668691)

Target: Retinoic Acid Receptor beta (RARB) (Retinoic Acid Receptor, beta (RARB))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Retinoic Acid Receptor beta antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Supershift Assay (SSA)

Clone: 8B-10B2

Product Details anti-Retinoic Acid Receptor beta Antibody

Binding Specificity: AA 413-448

Purpose: RAR-beta antibody (mAb) (Clone 8B-10B2)

Purification: Protein G Chromatography

Immunogen: This RAR-beta antibody was raised against amino acids 413-448 of human RAR-beta.

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1 μg/μL

Buffer: Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Storage: -20 °C

Storage Comment: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Expiry Date: 24 months

References for anti-Retinoic Acid Receptor beta antibody (ABIN2668691)

Boehm, Samama, Cribier, Rochette-Egly: "Retinoic-acid receptor beta expression in melanocytes." in: European journal of dermatology : EJD, Vol. 14, Issue 1, pp. 19-23, (2004) (PubMed).

Chakravarti, Mathur, Bahadur, Shukla, Rochette-Egly, Ralhan: "Expression of RARalpha and RARbeta in human oral potentially malignant and neoplastic lesions." in: International journal of cancer. Journal international du cancer, Vol. 91, Issue 1, pp. 27-31, (2001) (PubMed).

Target Details for Retinoic Acid Receptor beta

Target: Retinoic Acid Receptor beta (RARB) (Retinoic Acid Receptor, beta (RARB))

Alternative Name: RAR-beta

Background: RAR-b (HAP, NR1B2) is a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. RAR-b localizes to the cytoplasm and to subnuclear compartments. RAR-b binds retinoic acid, the biologically active form of vitamin A which mediates cellular signaling in embryonic morphogenesis, cell growth and differentiation. It is thought that RAR-b limits growth of many cell types by regulating gene expression.

Molecular Weight: 50 kDa

Gene ID: 5915

NCBI Accession: NP_000956

Pathways: Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway