Kdm6b antibody (AA 1028-1684)

Catalog No. ABIN2668350

This Mouse Monoclonal antibody specifically detects Kdm6b in WB. It exhibits reactivity toward Human and Mouse.

Quick Overview for Kdm6b antibody (AA 1028-1684) (ABIN2668350)

Target: Kdm6b (Lysine (K)-Specific Demethylase 6B (Kdm6b))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This Kdm6b antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 67-A2

Product Details anti-Kdm6b Antibody

Binding Specificity: AA 1028-1684

Purpose: JMJD3 / KDM6B antibody (mAb) (Clone 67-A2)

Purification: Protein A Chromatography

Immunogen: This antibody was raised against a recombinant protein corresponding to amino acids 1028-1684 of human JMJD3 / KDM6B.

Isotype: IgG1

Application Details

Application Notes: WB: 0.5 - 2 μg/mL dilution

Restrictions: For Research Use only

Handling

Concentration: 1 μg/μL

Buffer: Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Storage: -20 °C

Storage Comment: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Expiry Date: 24 months

Target Details for Kdm6b

Target: Kdm6b (Lysine (K)-Specific Demethylase 6B (Kdm6b))

Alternative Name: JMJD3 / KDM6B

Background: JMJD3 / KMD6B (Jumonji domain-containing protein 3 lysine (K)-specific demethylase 6B) Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation.

Molecular Weight: 150 kDa

Gene ID: 23135

NCBI Accession: NP_001073893

Pathways: Warburg Effect