RECQL2 antibody

Catalog No. ABIN2668372

There is 1 publication for this product available. The Mouse Monoclonal anti-RECQL2 antibody is suitable to detect RECQL2 in samples from Human. It has been validated for WB, IHC, IF and ICC.

Quick Overview for RECQL2 antibody (ABIN2668372)

Target: RECQL2 (WRN) (Werner syndrome RecQ like helicase (WRN))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This RECQL2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: 195C

Product Details anti-RECQL2 Antibody

Purpose: WRN antibody (mAb) (Clone 195C)

Purification: Protein G Chromatography

Immunogen: This WRN antibody was raised against a recombinant protein corresponding to amino acids 1072 - 1432 of human WRN.

Isotype: IgG1

Application Details

Application Notes: ICC/IF: 0.5 μg/mL dilution IHC(P): User optimization required WB: 0.5 - 2 μg/mL dilution

Restrictions: For Research Use only

Handling

Concentration: 1 μg/μL

Buffer: Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Storage: -20 °C

Storage Comment: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Expiry Date: 24 months

References for anti-RECQL2 antibody (ABIN2668372)

Opresko, Calvo, von Kobbe: "Role for the Werner syndrome protein in the promotion of tumor cell growth." in: Mechanisms of ageing and development, Vol. 128, Issue 7-8, pp. 423-36, (2007) (PubMed).

Target Details for RECQL2

Target: RECQL2 (WRN) (Werner syndrome RecQ like helicase (WRN))

Alternative Name: WRN

Background: WRN protein is a RECQ helicase that contains 3' to 5' helicase activity and DNA-dependent ATPase activity. WRN takes part in many processes, including DNA replication, recombination, repair, and telomere maintenance. Mutations in the gene encoding WRN cause an autosomal recessive segmental progeria called Werner syndrome (WS). WS patients prematurely develop atrophic skin, thin gray hair, osteoporosis, type II diabetes, cataracts, arteriosclerosis and cancer.

Molecular Weight: 162 kDa

Gene ID: 7486

NCBI Accession: NP_000544

Pathways: DNA Damage Repair