CHD2 antibody (C-Term)

Catalog No. ABIN2667961

The Rabbit Polyclonal anti-CHD2 antibody is suitable to detect CHD2 in samples from Human. It has been validated for WB.

Quick Overview for CHD2 antibody (C-Term) (ABIN2667961)

Target: CHD2 (Chromodomain Helicase DNA Binding Protein 2 (CHD2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHD2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CHD2 Antibody

Binding Specificity: C-Term

Purpose: CHD2 antibody (pAb)

Purification: Affinity Purified

Immunogen: This CHD2 antibody (pAb) was raised against a peptide corresponding to the C-terminus of human CHD2.

Isotype: IgG

Application Details

Application Notes: WB: 1:250 - 1:1,000 dilution The addition of 0.1 % Tween 20 in all blocking solutions may reduce background. Individual optimization may be required.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Storage: -20 °C

Storage Comment: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Expiry Date: 24 months

Target Details for CHD2

Target: CHD2 (Chromodomain Helicase DNA Binding Protein 2 (CHD2))

Alternative Name: CHD2

Background: CHD (Chromo-ATPase/Helicase-DNA-binding) proteins, which are ATP-dependent chromatin remodeling factors implicated in RNA polymerase II transcriptional regulation, are characterized by the presence of a double chromodomains (Chromatin Organization Modifier) and SNF2-related helicase/ATPase domains. The CHD1/CHD2 sub-family of CHD proteins also contain a C-terminal DNA binding domain that recognizes AT-rich sequences. CHD proteins alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template. CHD2 is required for normal development of mouse embryos.

Molecular Weight: 260 kDa

Gene ID: 1106

NCBI Accession: NP_001262