Aurora Kinase B antibody (C-Term)

Catalog No. ABIN2668672

The Rabbit Polyclonal anti-Aurora Kinase B antibody is suitable to detect Aurora Kinase B in samples from Human and Mouse. It has been validated for WB, IF and ICC.

Quick Overview for Aurora Kinase B antibody (C-Term) (ABIN2668672)

Target: Aurora Kinase B (AURKB)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Aurora Kinase B antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Product Details anti-Aurora Kinase B Antibody

Binding Specificity: C-Term

Purpose: Aurora B antibody (pAb)

Purification: Unpurified

Immunogen: This Aurora B antibody was raised against a peptide including the C-terminus of human Aurora B.

Application Details

Application Notes: ICC/IF: 1:200 - 1:1,000 dilution WB: 1:500 - 1:5,000 dilution

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit serum containing 30 % glycerol and 0.035 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Storage: -20 °C

Storage Comment: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Expiry Date: 24 months

Target Details for Aurora Kinase B

Target: Aurora Kinase B (AURKB)

Alternative Name: Aurora B

Background: Aurora B (Aurora Kinase B, AurB, ARK2) is a Ser/Thr kinase that is part of the chromosomal passenger complex that associates with chromosomes and is an important regulator of mitosis and meiosis. Aurora B becomes concentrated at the centromere during the onset of mitosis, but relocates to the spindle midzone during anaphase. Aurora B phosphorylates a number of substrates, including INCENP, CENP-A, and Histone H3. Misregulation of Aurora B activity can lead to chromosome instability and is implicated in a number of cancers.

Molecular Weight: 49 kDa

Gene ID: 9212

NCBI Accession: NP_004208

Pathways: TCR Signaling, Cell Division Cycle, Maintenance of Protein Location, Hepatitis C, Toll-Like Receptors Cascades