IRF3 antibody (AA 306-312)

Catalog No. ABIN2668684

There is 1 publication for this product available. The Rabbit Polyclonal anti-IRF3 antibody is suitable to detect IRF3 in samples from Human. It has been validated for WB and ChIP.

Quick Overview for IRF3 antibody (AA 306-312) (ABIN2668684)

Target: IRF3 (Interferon Regulatory Factor 3 (IRF3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IRF3 antibody is un-conjugated

Application: Western Blotting (WB), Chromatin Immunoprecipitation (ChIP)

Product Details anti-IRF3 Antibody

Binding Specificity: AA 306-312

Purpose: IRF-3 antibody (pAb)

Purification: Unpurified

Immunogen: This IRF-3 antibody was raised against a peptide corresponding to residues 306-312 of human IRF-3.

Application Details

Application Notes: WB: 1:1,000 - 1:2,000 dilution

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit serum containing 30 % glycerol and 0.035 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Storage: -20 °C

Storage Comment: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Expiry Date: 24 months

References for anti-IRF3 antibody (ABIN2668684)

Goriely, Molle, Nguyen, Albarani, Haddou, Lin, De Wit, Flamand, Willems, Goldman: "Interferon regulatory factor 3 is involved in Toll-like receptor 4 (TLR4)- and TLR3-induced IL-12p35 gene activation." in: Blood, Vol. 107, Issue 3, pp. 1078-84, (2006) (PubMed).

Target Details for IRF3

Target: IRF3 (Interferon Regulatory Factor 3 (IRF3))

Alternative Name: IRF-3

Background: IRF-3 (Interferon regulatory factor 3 or IRF3) is a member of the IRF family of transcription factors that include IRF-1, IRF-6 and IRF-7. IRF-3 that has been phosphorylated at serine/threonine forms a complex with CREBBP and translocates to the nucleus to activate transcription of interferon-induced genes.

Molecular Weight: 50 kDa

Gene ID: 3661

NCBI Accession: NP_001562

Pathways: TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades