IL3RA antibody

Catalog No. ABIN2688933

There are 2+ publications for this product available. The Mouse Monoclonal anti-IL3RA antibody is suitable to detect IL3RA in samples from Human. It has been validated for FACS, WB and IF.

Quick Overview for IL3RA antibody (ABIN2688933)

Target: IL3RA (Interleukin 3 Receptor, alpha (IL3RA))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL3RA antibody is un-conjugated

Application: Flow Cytometry (FACS), Western Blotting (WB), Immunofluorescence (IF)

Clone: 9F5

Product Details anti-IL3RA Antibody

Characteristics: Reacts with the 70 kDa IL-3 receptor α chain(IL-3Rα), which associates with the 120-140 kDa β subunit. The β chain is shared with the receptors for interleukins IL-5 and GM-CSF. IL-3Rα is expressed on myeloid precursors, basophils, mast cells, macrophages, and megakaryocytes. Reports indicate that IL-3Rα is also expressed on lymphocytes. IL-3R plays an important role in hematopoietic progenitor cell growth and differentiation. This antibody does not block binding of IL-3 to the IL-3 receptor. Log Fluorescence Intensity Profile of TF-1(erythroid leukemia) cells analyzed on a FACScan (

BD Pharmingen™ Purified Mouse Anti-Human CD123 - Purified - Clone 9F5 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.5 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 4°C.

References for anti-IL3RA antibody (ABIN2688933)

Macardle, Chen, Shih, Huang, Weedon, Sun, Lopez, Zola: "Characterization of human leucocytes bearing the IL-3 receptor." in: Cellular immunology, Vol. 168, Issue 1, pp. 59-68, (1996) (PubMed).

Sun, Woodcock, Rapoport, Stomski, Korpelainen, Bagley, Goodall, Smith, Gamble, Vadas, Lopez: "Monoclonal antibody 7G3 recognizes the N-terminal domain of the human interleukin-3 (IL-3) receptor alpha-chain and functions as a specific IL-3 receptor antagonist." in: Blood, Vol. 87, Issue 1, pp. 83-92, (1996) (PubMed).

Target Details for IL3RA

Target: IL3RA (Interleukin 3 Receptor, alpha (IL3RA))

Alternative Name: CD123

Background: Synonyms: IL-3 Receptor α chain

Pathways: JAK-STAT Signaling