NCR1 antibody (Natural Cytotoxicity Triggering Receptor 1)

Details for Product anti-NCR1 Antibody No. ABIN2689196
Antigen
  • CD335
  • LY94
  • NK-p46
  • NKP46
  • Ly94
  • NKp46
  • KILR-1
  • Nk-p46
  • Nkp46
  • natural cytotoxicity triggering receptor 1
  • NCR1
  • Ncr1
Alternatives
anti-Cow (Bovine) NCR1 antibody for Flow Cytometry
Reactivity
Human
109
60
24
14
4
3
Host
Mouse
82
46
24
Clonality (Clone)
Monoclonal ()
Conjugate
This NCR1 antibody is un-conjugated
16
11
8
6
3
3
3
3
3
3
2
1
1
1
1
1
1
Application
Flow Cytometry (FACS)
70
64
31
17
15
13
7
6
6
5
5
2
1
Options
Brand BD Pharmingen™
Clone 9E2-NKp46
Isotype IgG1, kappa
Characteristics The 9E2/Nkp46 monoclonal antibody specifically binds to CD335. CD335 is also known as the Natural killer cell p46-related protein (NKp46) and the Natural cytotoxicity triggering receptor 1 (NCR1). CD335 is a 46 kDa type I membrane glycoprotein that is expressed on resting and activated NK cells. Its extracellular region contains two C2-type, Ig-like domains. The transmembrane domain contains a positively charged amino acid (Arg) which could be involved in stabilizing the association with CD3ζ. Its intracellular region does not contain immunoreceptor tyrosine-based activating motifs (ITAM), but it is linked to intracytoplasmic transduction machinery by its association with CD3ζ and FcεRIγ adaptor proteins. CD335 along with NKp30 and NKp44 are referred to as natural cytotoxicity receptors (NCR). These receptors play very important roles in cells that kill virus-infected target cells, tumor cells and MHC-class I-unprotected cells. Profile of CD335 (NKp46) reactivity on peripheral blood lymphocytes analyzed by flow cytometry. Second step staining with Cat. No. 555988.

BD Pharmingen™ Purified Mouse Anti-Human CD335 (NKp46) - Purified - Clone 9E2/NKp46 (also known as 9-E2) - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Plasmids, Primers & others Plasmids, Primers & others NCR1 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name CD335 NKp46 (NCR1 Antibody Abstract)
Pathways Regulation of Leukocyte Mediated Immunity
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Aqueous buffered solution containing ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store undiluted at 4°C.
Product cited in: Mandelboim, Porgador: "NKp46." in: The international journal of biochemistry & cell biology, Vol. 33, Issue 12, pp. 1147-50, 2001 (PubMed).

Nakajima, Cella, Bouchon, Grierson, Lewis, Duckett, Cohen, Colonna: "Patients with X-linked lymphoproliferative disease have a defect in 2B4 receptor-mediated NK cell cytotoxicity." in: European journal of immunology, Vol. 30, Issue 11, pp. 3309-18, 2001 (PubMed).

Sivori, Pende, Bottino, Marcenaro, Pessino, Biassoni, Moretta, Moretta et al.: "NKp46 is the major triggering receptor involved in the natural cytotoxicity of fresh or cultured human NK cells. Correlation between surface density of NKp46 and natural cytotoxicity against ..." in: European journal of immunology, Vol. 29, Issue 5, pp. 1656-66, 1999 (PubMed).

Sivori, Vitale, Morelli, Sanseverino, Augugliaro, Bottino, Moretta, Moretta: "p46, a novel natural killer cell-specific surface molecule that mediates cell activation." in: The Journal of experimental medicine, Vol. 186, Issue 7, pp. 1129-36, 1997 (PubMed).

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