CD57 antibody

Catalog No. ABIN2689344

Product Details anti-CD57 Antibody

Target: CD57 (B3GAT1) (beta-1,3-Glucuronyltransferase 1 (Glucuronosyltransferase P) (B3GAT1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD57 antibody is un-conjugated

Application: Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Functional Studies (Func)

Brand: BD Pharmingen™

Characteristics: Anti-HNK-1 monoclonal antibody recognizes a 110 kD glycoprotein (CD57) that is expressed on a subset of natural killer (NK) lymphocytes and T lymphocytes. It also recognizes epitopes on neural or neuroectodermal tumors including neurofibromas, malignant melanomas, malignant peripheral neuroectodermal tumors, Ewing's sarcomas, and small-cell lung carcinomas. Anti-HNK-1 monoclonal antibody also recognizes a carbohydrate epitope on subpopulations of several cell-adhesion molecules including N-CAM and myelin-associated glycoprotein (MAG).

BD Pharmingen™ Purified Mouse Anti-Human CD57 - Purified - Clone HNK-1 - Isotype Mouse IgM, κ - Reactivity Hu - 0.2 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Membrane extracts of the HSB-2 T-lymphoblastoid cell line

Clone: HNK

Isotype: IgM kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 4°C.

References for anti-CD57 antibody (ABIN2689344)

Mechtersheimer, Staudter, Möller: "Expression of the natural killer cell-associated antigens CD56 and CD57 in human neural and striated muscle cells and in their tumors." in: Cancer research, Vol. 51, Issue 4, pp. 1300-7, (1991) (PubMed).

Jin, Hemperly, Lloyd: "Expression of neural cell adhesion molecule in normal and neoplastic human neuroendocrine tissues." in: The American journal of pathology, Vol. 138, Issue 4, pp. 961-9, (1991) (PubMed).

Pinto, Grant, Hayes, Schell, Parham: "Immunohistochemical expression of neuron-specific enolase and Leu 7 in Ewing's sarcoma of bone." in: Cancer, Vol. 64, Issue 6, pp. 1266-73, (1989) (PubMed).

Schubert, Zimmermann, Cramer, Starzinski-Powitz: "Lymphocyte antigen Leu-19 as a molecular marker of regeneration in human skeletal muscle." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 86, Issue 1, pp. 307-11, (1989) (PubMed).

Swanson, Manivel, Wick: "Immunoreactivity for Leu-7 in neurofibrosarcoma and other spindle cell sarcomas of soft tissue." in: The American journal of pathology, Vol. 126, Issue 3, pp. 546-60, (1987) (PubMed).

Hemperly, Murray, Edelman, Cunningham: "Sequence of a cDNA clone encoding the polysialic acid-rich and cytoplasmic domains of the neural cell adhesion molecule N-CAM." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 83, Issue 9, pp. 3037-41, (1986) (PubMed).

Lanier, Le, Civin, Loken, Phillips: "The relationship of CD16 (Leu-11) and Leu-19 (NKH-1) antigen expression on human peripheral blood NK cells and cytotoxic T lymphocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 136, Issue 12, pp. 4480-6, (1986) (PubMed).

Manara, De Panfilis, Ferrari: "Ultrastructural characterization of human large granular lymphocyte subsets defined by the expression of HNK-1 (Leu-7), Leu-11, or both HNK-1 and Leu-11 antigens." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 33, Issue 11, pp. 1129-33, (1985) (PubMed).

Smolle, Walter, Kerl: "Myelin-associated glycoprotein in neurogenic tumours of the skin: an immunohistological study using Leu-7 monoclonal antibody." in: Archives of dermatological research, Vol. 277, Issue 2, pp. 141-2, (1985) (PubMed).

Lipinski, Braham, Caillaud, Carlu, Tursz: "HNK-1 antibody detects an antigen expressed on neuroectodermal cells." in: The Journal of experimental medicine, Vol. 158, Issue 5, pp. 1775-80, (1983) (PubMed).

Lanier, Le, Phillips, Warner, Babcock: "Subpopulations of human natural killer cells defined by expression of the Leu-7 (HNK-1) and Leu-11 (NK-15) antigens." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 131, Issue 4, pp. 1789-96, (1983) (PubMed).

Target Details for CD57

Target: CD57 (B3GAT1) (beta-1,3-Glucuronyltransferase 1 (Glucuronosyltransferase P) (B3GAT1))

Alternative Name: CD57 (B3GAT1 Products)

Synonyms: CD57 antibody, GLCATP antibody, GLCUATP antibody, HNK1 antibody, LEU7 antibody, NK-1 antibody, NK1 antibody, 0710007K08Rik antibody, AI846286 antibody, GlcAT-P antibody, Glcatp antibody, Hnk1 antibody, Hnk-1 antibody, b3gat1 antibody, si:dkey-22o20.1 antibody, cd57 antibody, glcatp antibody, glcuatp antibody, hnk-1 antibody, hnk1 antibody, leu7 antibody, nk-1 antibody, nk1 antibody, beta-1,3-glucuronyltransferase 1 antibody, beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) antibody, beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) a antibody, beta-1,3-glucuronyltransferase 1 L homeolog antibody, B3GAT1 antibody, B3gat1 antibody, b3gat1a antibody, b3gat1.L antibody

Pathways: Glycosaminoglycan Metabolic Process