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METTL14 antibody (AA 21-120) (HRP)

METTL14 Reactivity: Human IHC (fro), IHC (p), WB Host: Rabbit Polyclonal HRP
Catalog No. ABIN2690004
$438.15
Plus shipping costs $45.00
100 μL
Shipping to: United States
Delivery in 11 to 16 Business Days
  • Target See all METTL14 Antibodies
    METTL14 (Methyltransferase Like 14 (METTL14))
    Binding Specificity
    • 14
    • 6
    • 1
    • 1
    • 1
    AA 21-120
    Reactivity
    • 25
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 24
    • 1
    Rabbit
    Clonality
    • 24
    • 1
    Polyclonal
    Conjugate
    • 8
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This METTL14 antibody is conjugated to HRP
    Application
    • 13
    • 13
    • 8
    • 6
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
    Predicted Reactivity
    Mouse,Rat,Cow,Pig,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from mouse Mettl14
    Isotype
    IgG
  • Application Notes
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Handling Advice
    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
    Storage
    -20 °C/-80 °C
    Storage Comment
    Store at -20°C, for long storage, store at -80°C. Avoid multiple freeze-thaw cycles
    Expiry Date
    12 months
  • Target
    METTL14 (Methyltransferase Like 14 (METTL14))
    Alternative Name
    Mettl14 (METTL14 Products)
    Synonyms
    RGD1304822, G430022H21Rik, mKIAA1627, zgc:77296, methyltransferase like 14, methyltransferase like 14 L homeolog, Mettl14, mettl14.L, METTL14, mettl14
    Background

    N6-methyltransferase that methylates adenosine residues of some mRNAs and acts as a regulator of the circadian clock and differentiation of embryonic stem cells. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in the efficiency of mRNA splicing, processing and mRNA stability. M6A regulates the length of the circadian clock: acts as a early pace-setter in the circadian loop (By similarity). M6A also acts as a regulator of mRNA stability: in embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization (PubMed:24394384).

    Subcellular location: Nucleus

    Synonyms: mKIAA1627, G430022H21Rik, N6-adenosine-methyltransferase subunit METTL14, Methyltransferase-like protein 14, Mettl14, Kiaa1627

    Gene ID
    210529
    UniProt
    Q3UIK4
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