RFXANK antibody

Catalog No. ABIN2716139

The Mouse Monoclonal anti-RFXANK antibody is suitable to detect RFXANK in samples from Human. It has been validated for WB, IF, IHC and FACS.

Quick Overview for RFXANK antibody (ABIN2716139)

Target: RFXANK (Regulatory Factor X-Associated Ankyrin Containing Protein (RFXANK))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This RFXANK antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Clone: 3C10

Product Details anti-RFXANK Antibody

Characteristics: Homo sapiens regulatory factor X-associated ankyrin-containing protein (RFXANK), transcript variant 2

Purification: Purified from mouse ascites fluids by affinity chromatography

Immunogen: Full length human recombinant protein of human RFXANK(NP_604389) produced in HEK293T cell.

Isotype: IgG1

Application Details

Application Notes: WB 1:500, IHC 1:150, IF 1:100, FLOW 1:100,

Comment:

The concentration of the product may vary between diferrent lots.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5-1.0 mg/mL

Buffer: PBS (PH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for RFXANK

Target: RFXANK (Regulatory Factor X-Associated Ankyrin Containing Protein (RFXANK))

Alternative Name: RFXANK

Background: Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. This protein contains ankyrin repeats involved in protein-protein interactions. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group B. Two transcript variants encoding different isoforms have been described for this gene, with only one isoform showing activation activity.

Molecular Weight: 25.4 kDa

Gene ID: 8625

NCBI Accession: NM_134440

HGNC: 8625