CDKN2B antibody

Catalog No. ABIN2718414

The Mouse Monoclonal anti-CDKN2B antibody (Clone 3E4) (ABIN2718414) specifically detects CDKN2B in WB and FACS. The antibody is reactive with Human samples.

Quick Overview for CDKN2B antibody (ABIN2718414)

Target: CDKN2B (Cyclin-Dependent Kinase Inhibitor 2B (p15, Inhibits CDK4) (CDKN2B))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CDKN2B antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Clone: 3E4

Product Details anti-CDKN2B Antibody

Characteristics: Homo sapiens cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (CDKN2B), transcript variant 1

Purification: Purified from mouse ascites fluids by affinity chromatography

Immunogen: Full length human recombinant protein of human CDKN2B(NP_004927) produced in HEK293T cell.

Isotype: IgG1

Application Details

Application Notes: WB 1:2000, FLOW 1:100,

Comment:

The concentration of the product may vary between diferrent lots.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5-1.0 mg/mL

Buffer: PBS (PH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for CDKN2B

Target: CDKN2B (Cyclin-Dependent Kinase Inhibitor 2B (p15, Inhibits CDK4) (CDKN2B))

Alternative Name: CDKN2B

Background: This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.

Molecular Weight: 14.5 kDa

Gene ID: 1030

NCBI Accession: NM_004936

HGNC: 1030

Pathways: Cell Division Cycle, Mitotic G1-G1/S Phases