FMR1 antibody (AA 36-279)

Catalog No. ABIN2721254

The Mouse Monoclonal anti-FMR1 antibody (Clone 1D10) (ABIN2721254) specifically detects FMR1 in WB and IHC. The antibody is reactive with Human, Mouse, Rat, Dog and Monkey samples.

Quick Overview for FMR1 antibody (AA 36-279) (ABIN2721254)

Target: FMR1 (Fragile X Mental Retardation 1 (FMR1))

Reactivity: Human, Mouse, Rat, Dog, Monkey

Host: Mouse

Clonality: Monoclonal

Conjugate: This FMR1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: 1D10

Product Details anti-FMR1 Antibody

Binding Specificity: AA 36-279

Characteristics: Homo sapiens fragile X mental retardation 1 (FMR1), transcript variant ISO1

Purification: Purified from mouse ascites fluids by affinity chromatography

Immunogen: Human recombinant protein fragment corresponding to amino acids 36-279 of human FMR1(NP_002015) produced in E.coli.

Isotype: IgG2b

Application Details

Application Notes: WB 1:500~2000, IHC 1:50,

Comment:

The concentration of the product may vary between diferrent lots.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5-1.0 mg/mL

Buffer: PBS (PH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for FMR1

Target: FMR1 (Fragile X Mental Retardation 1 (FMR1))

Alternative Name: FMR1

Background: The protein encoded by this gene binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene.

Molecular Weight: 71 kDa

Gene ID: 2332

NCBI Accession: NM_002024

HGNC: 2332

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development