EPH Receptor A7 antibody

Catalog No. ABIN272234

The Rabbit Polyclonal anti-EPH Receptor A7 antibody is suitable to detect EPH Receptor A7 in samples from Human, Mouse and Rat. It has been validated for WB.

Quick Overview for EPH Receptor A7 antibody (ABIN272234)

Target: EPH Receptor A7 (EPHA7)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EPH Receptor A7 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-EPH Receptor A7 Antibody

Specificity: This antibody detects endogenous levels of EphA7 protein. (region surrounding Glu477)

Cross-Reactivity (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity Chromatography using epitope-specific immunogen.

Application Details

Application Notes: ELISA: 1/40000-1/60000. Western Blot: 1/500-1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for EPH Receptor A7

Target: EPH Receptor A7 (EPHA7)

Alternative Name: EPHA7

Background: The Eph subfamily represents the largest group of receptor protein tyrosine kinases identified to date. The Eph subfamily receptors of human origin (and their murine/avian homologs) include EphA1 (Eph), EphA2 (Eck), EphA3 (Hek4), EphA4 (Hek8), EphA5 (Hek7), EphA6 (Hek12), EphA7 (Hek11/MDK1), EphA8(Hek3), EphB1 (Hek6), EphB2 (Hek5), EphB3 (Cek10, Hek2), EphB4 (Htk), EphB5(Hek9) and EphB6 (Mep). EphAs are a family of receptor tyrosine kinases that are involved in axonal guidance during development. These receptors and their ligands, the ephrins, act via repulsive mechanisms to guide growing axons towards their appropriate targets and allow for the correct developmental connections to be made. Ligand binding to an Eph receptor results in tyrosine phosphorylation of the kinase domain, and repulsion of axonal growth cones and migrating cells. During neurulation, ephrin-A5 is coexpressed with its cognate receptor EphA7 in cells at the edges of the dorsal neural folds. Three different EphA7 splice variants, a full-length form and two truncated versions lacking kinase domains, are expressed in the neural folds.Synonyms: EHK3, EPH homology kinase 3, Ephrin type-A receptor 7, HEK11, Receptor protein-tyrosine kinase HEK11, Tyrosine-protein kinase receptor EHK-3

Molecular Weight: approx. 112 kDa

Gene ID: 2045

NCBI Accession: NP_004431

UniProt: Q15375

Pathways: RTK Signaling