RAD51 Homolog B antibody (AA 119-346)

Catalog No. ABIN2730412

The Mouse Monoclonal anti-RAD51 Homolog B antibody has been validated for WB, IF and FACS. It is suitable to detect RAD51 Homolog B in samples from Human.

Quick Overview for RAD51 Homolog B antibody (AA 119-346) (ABIN2730412)

Target: RAD51 Homolog B (Rad51B)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This RAD51 Homolog B antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: 7H4

Product Details anti-RAD51 Homolog B Antibody

Binding Specificity: AA 119-346

Characteristics: Homo sapiens RAD51 homolog B (S. cerevisiae) (RAD51B), transcript variant 3

Purification: Purified from mouse ascites fluids by affinity chromatography

Immunogen: Human recombinant protein fragment corresponding to amino acids 119-346 of human RAD51L1(NP_598193) produced in E.coli.

Isotype: IgG1

Application Details

Application Notes: WB 1:500, IF 1:100, FLOW 1:100,

Comment:

The concentration of the product may vary between diferrent lots.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5-1.0 mg/mL

Buffer: PBS (PH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for RAD51 Homolog B

Target: RAD51 Homolog B (Rad51B)

Alternative Name: RAD51L1

Background: The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. At least three alternatively spliced transcript variants encoding distinct isoforms have been observed.

Molecular Weight: 42 kDa

Gene ID: 5890

NCBI Accession: NM_133509

HGNC: 5890

Pathways: DNA Damage Repair