CD11b antibody

Catalog No. ABIN2742255

This anti-CD11b antibody is a Rat Monoclonal antibody detecting CD11b in FACS, IHC, IP, IF, IHC (fro), ELISA, Func and BR. Suitable for Human, Mouse, Rabbit, Baboon, Rhesus Monkey, Chimpanzee and Cynomolgus.

Quick Overview for CD11b antibody (ABIN2742255)

Target: CD11b (ITGAM) (Integrin alpha M (ITGAM))

Reactivity: Human, Mouse, Rabbit, Baboon, Rhesus Monkey, Chimpanzee, Cynomolgus

Host: Rat

Clonality: Monoclonal

Conjugate: This CD11b antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), ELISA, Functional Studies (Func), Blocking Reagent (BR)

Clone: M1-70

Product Details anti-CD11b Antibody

Specificity: Mouse ITGAM / CD11b

Purification: Protein G purified

Immunogen: B10 mouse spleen cells enriched for T lymphocytes.

Type of Immunogen: Cells

Isotype: IgG2b kappa

Application Details

Application Notes: Approved: Block, ELISA, Flo (0.5 - 1 μg/10 x10⁶), Func, IF (0.5 - 1 μg/mL), IHC, IHC-Fr (0.5 - 1 μg/mL), IP

Usage: CD11b is a cell adhesion molecule that acts as a receptor for cell surface ligands such as intracellular adhesion molecules (ICAMs) or soluble ligands. Integrins are heterodimeric proteins that contain an a chain and b chain. Integrin alpha-M (CD11b) combines with the Integrin beta-2 (CD18) to form a leukocyte-specific integrin referred to as macrophage receptor 1 (Mac-1), or inactivated-C3b (iC3b) receptor 3 (CR3). Integrin alpha-M/beta-2 is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. ELISA: Order BSA-free antibody format for coating.

Comment:

Target Species of Antibody: Mouse

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS,  pH 7.4, 0.1 mg/mL BSA, 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2°C to 8°C.

Target Details for CD11b

Target: CD11b (ITGAM) (Integrin alpha M (ITGAM))

Alternative Name: ITGAM / CD11b

Background: Name/Gene ID: ITGAM
Family: Integrin

Synonyms: ITGAM, Antigen CD11b (p170), CD11B, CD11b antigen, CR3A, Integrin alpha-M, MAC-1, MO1A, Neutrophil adherence receptor, MAC1A, SLEB6, CR-3 alpha chain

Gene ID: 3684

Pathways: Apoptosis, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation