Podoplanin antibody

Catalog No. ABIN2745557

This Hamster Monoclonal antibody specifically detects Podoplanin in WB, IHC, ELISA and IP. It exhibits reactivity toward Mouse.

Quick Overview for Podoplanin antibody (ABIN2745557)

Target: Podoplanin (PDPN)

Reactivity: Mouse

Host: Hamster

Clonality: Monoclonal

Conjugate: This Podoplanin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP)

Clone: RTD4E10

Product Details anti-Podoplanin Antibody

Purpose: anti-Podoplanin (mouse), mAb (RTD4E10)

Specificity: Recognizes mouse podoplanin. Does not cross-react with human podoplanin.

No Cross-Reactivity: Human

Cross-Reactivity (Details): Does not cross-react with human podoplanin.

Characteristics: Monoclonal Antibody. Recognizes mouse podoplanin. Does not cross-react with human podoplanin. Isotype: Hamster IgG. Clone: RTD4E10. Applications: ELISA, IHC, IP, WB. Lyophilized. Podoplanin is expressed on glomerular epithelial cells (podocytes), type I lung alveolar cells, lymphatic endothelial cells and numerous tumors, including colorectal tumors, squamous cell carcinomas, testicular seminoma and brain tumors. Podoplanin is the ligand for C-type lectin-like receptor 2 (CLEC-2). Their association is dependent on sialic acid on O-glycans of podoplanin. Through its association with CLEC-2, podoplanin induces platelet aggregation and tumor metastasis. Podoplanin is also necessary for lymphatic vessel formation, normal lung cell proliferation and alveolus formation at birth.

Purification: Protein G purified.

Immunogen: Murine thymic stromal cell line.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge vial prior to opening. Reconstitute with sterile water to a concentration of 0.1-1.0 mg/mL.

Buffer: Lyophilized.

Handling Advice: After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment:

+4°C

-20°C

Stable for at least 6 months after receipt when stored at -20°C.

Expiry Date: 6 months

Target Details for Podoplanin

Target: Podoplanin (PDPN)

Alternative Name: Podoplanin

Background:

Alternate Names/Synonyms: Glycoprotein 36, PA2.26 Antigen, Aggrus

Product Description: Podoplanin is expressed on glomerular epithelial cells (podocytes), type I lung alveolar cells, lymphatic endothelial cells and numerous tumors, including colorectal tumors, squamous cell carcinomas, testicular seminoma and brain tumors. Podoplanin is the ligand for C-type lectin-like receptor 2 (CLEC-2). Their association is dependent on sialic acid on O-glycans of podoplanin. Through its association with CLEC-2, podoplanin induces platelet aggregation and tumor metastasis. Podoplanin is also necessary for lymphatic vessel formation, normal lung cell proliferation and alveolus formation at birth.

Pathways: Dicarboxylic Acid Transport