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CD40 Ligand antibody

CD40LG Reactivity: Human, Non-Human Primate FACS, ICC, Func Host: Mouse Monoclonal 24-31 unconjugated
Catalog No. ABIN2752002
  • Target See all CD40 Ligand (CD40LG) Antibodies
    CD40 Ligand (CD40LG)
    Reactivity
    • 137
    • 76
    • 36
    • 9
    • 9
    • 7
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Non-Human Primate
    Host
    • 87
    • 61
    • 21
    • 15
    • 11
    • 1
    Mouse
    Clonality
    • 108
    • 82
    • 4
    Monoclonal
    Conjugate
    • 101
    • 22
    • 20
    • 15
    • 9
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CD40 Ligand antibody is un-conjugated
    Application
    • 105
    • 101
    • 54
    • 48
    • 38
    • 30
    • 19
    • 16
    • 15
    • 14
    • 13
    • 13
    • 7
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunocytochemistry (ICC), Functional Studies (Func)
    Specificity
    The mouse monoclonal antibody 24-31 detects an extracellular epitope of CD154 / CD40L (CD40-ligand), a 39 kDa cell surface type II glycoprotein expressed predominantly on activated CD4+ lymphocytes.
    Cross-Reactivity (Details)
    Human, Non-Human Primates
    Purification
    Purified by protein-A affinity chromatography.
    Purity
    > 95 % (by SDS-PAGE)
    Endotoxin Level
    Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.
    Immunogen
    human CD154 fusion protein
    Clone
    24-31
    Isotype
    IgG1
    Top Product
    Discover our top product CD40LG Primary Antibody
  • Application Notes
    Functional application: Blocking.
    Flow cytometry: Recommended dilution: 2-6 μg/mL
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4
    Preservative
    Azide free
    Storage
    4 °C
    Storage Comment
    Store at 2-8°C. Do not freeze.
  • Fernandes, Gomes, Butcher, Hernandez-Alcoceba, Chang, Kansopon, Newman, Stone, Tong: "Growth inhibition of human multiple myeloma cells by an oncolytic adenovirus carrying the CD40 ligand transgene." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 15, Issue 15, pp. 4847-56, (2009) (PubMed).

    Kum, Hung, Cameron, Chow et al.: "Temporal sequence and functional implications of V beta-specific T cell receptor down-regulation and costimulatory molecule expression following in vitro stimulation with the staphylococcal ..." in: The Journal of infectious diseases, Vol. 185, Issue 4, pp. 555-60, (2002) (PubMed).

    Brams, Black, Padlan, Hariharan, Leonard, Chambers-Slater, Noelle, Newman: "A humanized anti-human CD154 monoclonal antibody blocks CD154-CD40 mediated human B cell activation." in: International immunopharmacology, Vol. 1, Issue 2, pp. 277-94, (2001) (PubMed).

    Berner, Wolf, Hummel, Müller, Reuss-Borst: "Increased expression of CD40 ligand (CD154) on CD4+ T cells as a marker of disease activity in rheumatoid arthritis." in: Annals of the rheumatic diseases, Vol. 59, Issue 3, pp. 190-5, (2000) (PubMed).

    Barnhart, Ford, Bhushan, Song, Covey: "A polymorphic CD40 ligand (CD154) molecule mediates CD40-dependent signalling but interferes with the ability of soluble CD40 to functionally block CD154:CD40 interactions." in: Immunology, Vol. 99, Issue 1, pp. 54-61, (2000) (PubMed).

    Grammer, McFarland, Heaney, Darnell, Lipsky: "Expression, regulation, and function of B cell-expressed CD154 in germinal centers." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 8, pp. 4150-9, (1999) (PubMed).

    Kornbluth, Kee, Richman: "CD40 ligand (CD154) stimulation of macrophages to produce HIV-1-suppressive beta-chemokines." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 9, pp. 5205-10, (1998) (PubMed).

  • Target
    CD40 Ligand (CD40LG)
    Alternative Name
    CD154 / CD40L (CD40LG Products)
    Synonyms
    CD154 antibody, cd40l antibody, CD40L antibody, HIGM1 antibody, IGM antibody, IMD3 antibody, T-BAM antibody, TNFSF5 antibody, TRAP antibody, gp39 antibody, hCD40L antibody, CD40-L antibody, Cd40l antibody, Ly-62 antibody, Ly62 antibody, Tnfsf5 antibody, CD40 ligand antibody, TNF superfamily member 5 antibody, CD40LG antibody, cd40l antibody, Cd40lg antibody
    Background
    CD40 ligand,CD154 / CD40L (CD40 ligand) is a member of the tumor necrosis factor family, and is expressed primarily on activated CD4+ lymphocytes, but also on mast cells, basophils, eosinophils and human dendritic cells. Its counter-receptor CD40 is expressed on antigen presenting cells, including dendritic cells, macrophages, and B cells, and also on fibroblasts. Triggering of CD40 by CD40L causes maturation of dendritic cells and upregulation of antigen presentation in functions of the MHC and costimulatory molecules. CD40L also functions as a direct stimulating factor for T cells. CD40L plays also roles e.g. in antibody class switching and modulation of apoptosis in the germinal center.,CD40L, CD40 ligand, TNFSF5, Ly62, gp39, T-BAM
    Gene ID
    21947
    UniProt
    P27548
    Pathways
    NF-kappaB Signaling, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
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