PINK1 antibody (C-Term)

Catalog No. ABIN2764091

The Rabbit Polyclonal anti-PINK1 antibody has been validated for WB, IHC and EIA. It is suitable to detect PINK1 in samples from Human.

Quick Overview for PINK1 antibody (C-Term) (ABIN2764091)

Target: PINK1 (PTEN Induced Putative Kinase 1 (PINK1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PINK1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Enzyme Immunoassay (EIA)

Product Details anti-PINK1 Antibody

Binding Specificity: C-Term

Cross-Reactivity: Human

Characteristics: PTEN-induced putative kinase protein 1,Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitment to dysfunctional mitochondria to initiate their degradation. Defects in PINK1 are the cause of Parkinson disease type 6 (PARK6). A neurodegenerative disorder characterized by parkinsonian signs such as rigidity, resting tremor and bradykinesia. A subset of patients manifest additional symptoms including hyperreflexia, autonomic instability, dementia and psychiatric disturbances. Symptoms show diurnal fluctuation and can improve after sleep.

Purification: Antigen Immunoaffiinity Purification

Immunogen: Synthetic peptide derived from the C-terminal of the human PINK1 protein.

Isotype: IgG

Application Details

Application Notes: Antibody can be used for immunohistochemical staining (1-5 μg/mL). Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Handling

Buffer: Provided as solution in phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Details for PINK1

Target: PINK1 (PTEN Induced Putative Kinase 1 (PINK1))

Alternative Name: PINK1

UniProt: Q9BXM7

Pathways: Autophagy