POR antibody (Middle Region)
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- Target See all POR Antibodies
- POR (P450 (Cytochrome) Oxidoreductase (POR))
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Binding Specificity
- Middle Region
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Reactivity
- Human, Rat, Mouse, Cow, Dog, Rabbit, Guinea Pig, Horse, Zebrafish (Danio rerio)
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This POR antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- VVHTDIDAAK VYMGEMGRLK SYENQKPPFD AKNPFLAAVT TNRKLNQGTE
- Predicted Reactivity
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%
- Characteristics
- This is a rabbit polyclonal antibody against POR. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human POR
- Top Product
- Discover our top product POR Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 680 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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Cytochrome P450 system expression and DNA adduct formation in the liver of Zacco platypus following waterborne benzo(a)pyrene exposure: implications for biomarker determination." in: Environmental toxicology, Vol. 29, Issue 9, pp. 1032-42, (2014) (PubMed).
: "
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Cytochrome P450 system expression and DNA adduct formation in the liver of Zacco platypus following waterborne benzo(a)pyrene exposure: implications for biomarker determination." in: Environmental toxicology, Vol. 29, Issue 9, pp. 1032-42, (2014) (PubMed).
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- Target
- POR (P450 (Cytochrome) Oxidoreductase (POR))
- Alternative Name
- POR (POR Products)
- Synonyms
- CPR antibody, CYPOR antibody, P450R antibody, POR antibody, CCR antibody, CG11567 antibody, DMR antibody, DmCPR antibody, Dmel\\CG11567 antibody, NCPR antibody, P450 antibody, cpr antibody, zgc:110032 antibody, npr antibody, xpor antibody, 4933424M13Rik antibody, PORCINO antibody, T5J17.90 antibody, T5J17_90 antibody, TFC C antibody, TUBULIN-FOLDING COFACTOR C antibody, cytochrome p450 oxidoreductase antibody, P450 (cytochrome) oxidoreductase antibody, ADP-ribosylation factor interacting protein 2 antibody, Cytochrome P450 reductase antibody, P450 (cytochrome) oxidoreductase a antibody, P450 (cytochrome) oxidoreductase L homeolog antibody, NADPH--cytochrome P450 reductase antibody, C-CAP/cofactor C-like domain-containing protein antibody, POR antibody, Arfip2 antibody, Por antibody, Cpr antibody, pora antibody, por.L antibody, LOC100406157 antibody, por antibody, LOC100619047 antibody
- Background
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POR is an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this POR gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome.This gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CPR, CYPOR, DKFZp686G04235, FLJ26468, P450R
Protein Interaction Partner: UBC, CYP2C9, PGRMC1, STAT1, INSIG1, CYP3A4, CYP2E1, CYP2D6, CYP2C19, CYP2A6, CYP1A2, UBD, SUMO2, RABEPK, FANCC, CYB5A, CYP17A1, XRCC6, HMOX1,
Protein Size: 680 - Molecular Weight
- 77 kDa
- Gene ID
- 5447
- NCBI Accession
- NM_000941, NP_000932
- UniProt
- Q63HL4
- Pathways
- Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, SARS-CoV-2 Protein Interactome
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