ICMT antibody (Middle Region)

Catalog No. ABIN2773889

Cited in 1 publication. The Rabbit Polyclonal anti-ICMT antibody (ABIN2773889) specifically detects ICMT in WB. The antibody is reactive with Human, Rat, Mouse, Guinea Pig, Rabbit, Cow, Dog, Horse and Saccharomyces cerevisiae samples.

Quick Overview for ICMT antibody (Middle Region) (ABIN2773889)

Target: ICMT (Isoprenylcysteine Carboxyl Methyltransferase (ICMT))

Reactivity: Human, Rat, Mouse, Guinea Pig, Rabbit, Cow, Dog, Horse, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ICMT antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ICMT Antibody

Binding Specificity: Middle Region

Purpose: ICMT Antibody - middle region

Sequence: GSNFNHVVQN EKSDTHTLVT SGVYAWFRHP SYVGWFYWSI GTQVMLCNPI

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 79%

Characteristics: This is a rabbit polyclonal antibody against ICMT. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ICMT

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP46894-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-ICMT antibody (ABIN2773889)

Nuthalapaty, Lu, Ramin, Nuthalapaty, Ramin, Ramsey: "Is there a preferred gestational age threshold of viability?: a survey of maternal-fetal medicine providers." in: The journal of maternal-fetal & neonatal medicine, Vol. 20, Issue 4, pp. 293-7, (2007) (PubMed).

Target Details for ICMT

Target: ICMT (Isoprenylcysteine Carboxyl Methyltransferase (ICMT))

Alternative Name: ICMT

Background:

Background Information: ICMT is the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined.

Gene Name: Isoprenylcysteine carboxyl methyltransferase

Alternative Symbols: PCMT, PPMT, PCCMT, HSTE14, MST098, MSTP098

Protein Name: Protein-S-isoprenylcysteine O-methyltransferase

Molecular Weight: 32kDa

Gene ID: 23463

NCBI Accession: NP_036537

UniProt: O60725