RABGGTA antibody (N-Term)

Catalog No. ABIN2773937

There are 2+ publications for this product available. The Rabbit Polyclonal anti-RABGGTA antibody is suitable to detect RABGGTA in samples from Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse and Rabbit. It has been validated for WB.

Quick Overview for RABGGTA antibody (N-Term) (ABIN2773937)

Target: RABGGTA (Rab Geranylgeranyltransferase, alpha Subunit (RABGGTA))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RABGGTA antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-RABGGTA Antibody

Binding Specificity: N-Term

Purpose: RABGGTA Antibody - N-terminal region

Sequence: ELAFTDSLIT RNFSNYSSWH YRSCLLPQLH PQPDSGPQGR LPEDVLLKEL

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against RABGGTA. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human RABGGTA

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8109774

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-RABGGTA antibody (ABIN2773937)

Arora, Syed, Machhadieh, McKenna, Kowluru: "Rab-geranylgeranyl transferase regulates glucose-stimulated insulin secretion from pancreatic ? cells." in: Islets, Vol. 4, Issue 5, pp. 354-8, (2012) (PubMed).

Lachance, Cartier, Génier, Munger, Germain, Labrecque, Parent: "Regulation of ?2-adrenergic receptor maturation and anterograde trafficking by an interaction with Rab geranylgeranyltransferase: modulation of Rab geranylgeranylation by the receptor." in: The Journal of biological chemistry, Vol. 286, Issue 47, pp. 40802-13, (2011) (PubMed).

Target Details for RABGGTA

Target: RABGGTA (Rab Geranylgeranyltransferase, alpha Subunit (RABGGTA))

Alternative Name: RABGGTA

Background:

Targeted Subunit: alpha

Background Information: RABGGTA belongs to the protein prenyltransferase subunit alpha family and contains 6 PFTA repeats. RABGGTA catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively.

Gene Name: Rab geranylgeranyltransferase, alpha subunit

Alternative Symbols: PTAR3

Protein Name: Geranylgeranyl transferase type-2 subunit alpha

Molecular Weight: 65kDa

Gene ID: 5875

NCBI Accession: NP_878256

UniProt: Q92696