MYCNOS antibody (N-Term)

Catalog No. ABIN2773988

This Rabbit Polyclonal antibody specifically detects MYCNOS in WB. It exhibits reactivity toward Human.

Quick Overview for MYCNOS antibody (N-Term) (ABIN2773988)

Target: MYCNOS (MYCN Opposite Strand/antisense RNA (MYCNOS))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MYCNOS antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MYCNOS Antibody

Binding Specificity: N-Term

Purpose: MYCNOS Antibody - N-terminal region

Sequence: WGGETDASNP APALTACCAA EREANVEQGL AGRLLLCNYE RRLVRRCKIA

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against MYCNOS. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP51638-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for MYCNOS

Target: MYCNOS (MYCN Opposite Strand/antisense RNA (MYCNOS))

Alternative Name: MYCNOS

Background:

Background Information: The N-myc oncogene has been implicated in the pathogenesis of a number of human tumors, including childhood neuroblastoma and adult small cell lung cancer. Complementary DNA clones derived from a transcription unit, N-cym, located on the opposite DNA strand to N-myc have been characterized. There is extensive overlap between the 5' ends of the two transcription units. The N-cym gene, which can encode a 109-amino acid protein, is expressed during fetal development, as well as in tumor cell lines containing amplified N-myc loci, where it is expressed at very high levels. Although other examples of overlapping, opposite-strand eukaryotic genes exist, N-myc and N-cym are unique in that they appear to be coregulated in tumor cell lines under basal growth conditions and in response to the differentiating agent retinoic acid. This coregulation suggests that their protein products may be functionally interrelated during normal development and oncogenesis.

Gene Name: MYCN opposite strand/antisense RNA (non-protein coding)

Alternative Symbols: NCYM, NYCM, N-CYM, MYCN-AS1

Protein Name: N-cym protein

Molecular Weight: 12kDa

Gene ID: 10408

NCBI Accession: NP_006307

UniProt: P40205