APH1B antibody (C-Term)

Catalog No. ABIN2774063

Product Details anti-APH1B Antibody

Target: APH1B (Aph1b) (Anterior Pharynx Defective 1 Homolog B (Aph1b))

Binding Specificity: C-Term

Reactivity: Mouse, Human, Rat, Rabbit, Cow, Dog, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APH1B antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: YYGINLASAF IILVLMGTWA FLAAGGSCRS LKLCLLCQDK NFLLYNQRSR

Predicted Reactivity: Cow: 77%, Dog: 85%, Guinea Pig: 92%, Horse: 77%, Human: 100%, Mouse: 92%, Rabbit: 85%, Rat: 92%

Characteristics: This is a rabbit polyclonal antibody against APH1B. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 216 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for APH1B

Target: APH1B (Aph1b) (Anterior Pharynx Defective 1 Homolog B (Aph1b))

Alternative Name: APH1B (Aph1b Products)

Synonyms: APH-1B antibody, PRO1328 antibody, PSFL antibody, TAAV688 antibody, APH-1B' antibody, 2310057K14Rik antibody, Aph1c antibody, aph-1 homolog B, gamma-secretase subunit antibody, aph-1 homolog B, gamma secretase subunit antibody, aph1 homolog B, gamma secretase subunit antibody, APH1B antibody, Aph1b antibody

Background: This gene encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptors and beta-amyloid precursor protein.
Alias Symbols: APH-1B, DKFZp564D0372, FLJ33115, PRO1328, PSFL, TAAV688
Protein Interaction Partner: UBC, PSENEN, NCSTN, PSEN2, PSEN1,
Protein Size: 216

Molecular Weight: 23 kDa

Gene ID: 83464

NCBI Accession: NM_001145646, NP_001139118

UniProt: Q564N3

Pathways: Notch Signaling, Neurotrophin Signaling Pathway