NXT1 antibody (N-Term)

Catalog No. ABIN2774091

Product Details anti-NXT1 Antibody

Target: NXT1 (NTF2-Related Export Protein 1 (NXT1))

Binding Specificity: N-Term

Reactivity: Mouse, Human, Rat, Cow, Guinea Pig, Zebrafish (Danio rerio), Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NXT1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: GTATLVWNGN AVSGQESLSE FFEMLPSSEF QISVVDCQPV HDEATPSQTT

Predicted Reactivity: Cow: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against NXT1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human NXT1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 140 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for NXT1

Target: NXT1 (NTF2-Related Export Protein 1 (NXT1))

Alternative Name: NXT1 (NXT1 Products)

Background: The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in both RAN (Ras-related nuclear protein)- and CRM1 (required for chromosome region maintenance)-dependent pathways. It is found to stimulate the export of U1 snRNA in RAN- and CRM1-dependent pathways and the export of tRNA and mRNA in a CRM1-independent pathway. The encoded protein heterodimerizes with Tap protein and may regulate the ability of Tap protein to mediate nuclear mRNA export. The use of alternate polyadenylation sites has been found for this gene.
Alias Symbols: MTR2, P15
Protein Interaction Partner: NXF3, PAXIP1, UBC, STAU1, NXF1, DDOST, VPS36, XPO1, RAN, NXF2,
Protein Size: 140

Molecular Weight: 16 kDa

Gene ID: 29107

NCBI Accession: NM_013248, NP_037380

UniProt: Q9UKK6