ANKRD15 antibody (C-Term)

Catalog No. ABIN2774113

The Rabbit Polyclonal anti-ANKRD15 antibody is suitable to detect ANKRD15 in samples from Human, Mouse, Rat, Cow, Horse, Pig, Dog, Guinea Pig and Rabbit. It has been validated for WB.

Quick Overview for ANKRD15 antibody (C-Term) (ABIN2774113)

Target: ANKRD15 (Ankyrin Repeat Domain 15 (ANKRD15))

Reactivity: Human, Mouse, Rat, Cow, Horse, Pig, Dog, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ANKRD15 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ANKRD15 Antibody

Binding Specificity: C-Term

Purpose: KANK1 Antibody - C-terminal region

Sequence: STALSIALEA GHKDIAVLLY AHVNFAKAQS PGTPRLGRKT SPGPTHRGSF

Predicted Reactivity: Cow: 100%, Dog: 86%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against KANK1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of human KANK1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP55572-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for ANKRD15

Target: ANKRD15 (Ankyrin Repeat Domain 15 (ANKRD15))

Alternative Name: KANK1

Background:

Background Information: The protein encoded by this gene belongs to the Kank family of proteins, which contain multiple ankyrin repeat domains. This family member functions in cytoskeleton formation by regulating actin polymerization. This gene is a candidate tumor suppressor for renal cell carcinoma. Mutations in this gene cause cerebral palsy spastic quadriplegic type 2, a central nervous system development disorder. A t(5,9) translocation results in fusion of the platelet-derived growth factor receptor beta gene (PDGFRB) on chromosome 5 with this gene in a myeloproliferative neoplasm featuring severe thrombocythemia. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 20.

Gene Name: KN motif and ankyrin repeat domains 1

Alternative Symbols: KANK, CPSQ2, ANKRD15

Protein Name: KN motif and ankyrin repeat domain-containing protein 1

Molecular Weight: 36kDa

Gene ID: 23189

NCBI Accession: NP_001243805

UniProt: Q14678

Pathways: Regulation of Actin Filament Polymerization