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CNTF Receptor alpha antibody (C-Term)

CNTFR Reactivity: Human, Mouse, Rat, Dog, Rabbit, Cow, Horse, Guinea Pig, Sheep WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2774276
  • Target See all CNTF Receptor alpha (CNTFR) Antibodies
    CNTF Receptor alpha (CNTFR) (Ciliary Neurotrophic Factor Receptor (CNTFR))
    Binding Specificity
    • 15
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    Human, Mouse, Rat, Dog, Rabbit, Cow, Horse, Guinea Pig, Sheep
    Host
    • 42
    • 2
    • 1
    Rabbit
    Clonality
    • 44
    • 1
    Polyclonal
    Conjugate
    • 14
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This CNTF Receptor alpha antibody is un-conjugated
    Application
    • 28
    • 14
    • 14
    • 13
    • 5
    • 5
    • 4
    • 2
    • 2
    • 1
    Western Blotting (WB)
    Sequence
    VAAHATPWTE EPRHLTTEAQ AAETTTSTTS SLAPPPTTKI CDPGELGSGG
    Predicted Reactivity
    Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 93%, Sheep: 93%
    Characteristics
    This is a rabbit polyclonal antibody against CNTFR. It was validated on Western Blot.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the C terminal region of human CNTFR
    Top Product
    Discover our top product CNTFR Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 372 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    CNTF Receptor alpha (CNTFR) (Ciliary Neurotrophic Factor Receptor (CNTFR))
    Alternative Name
    CNTFR (CNTFR Products)
    Synonyms
    CNTFR-alpha antibody, CNTFRALPHA antibody, Cntfralpha antibody, cb549 antibody, fj33e02 antibody, sb:cb549 antibody, wu:fj33e02 antibody, si:bz76a6.1 antibody, si:dz248f2.1 antibody, si:rp71-76a6.1 antibody, ciliary neurotrophic factor receptor antibody, ciliary neurotrophic factor receptor L homeolog antibody, CNTFR antibody, cntfr.L antibody, Cntfr antibody, cntfr antibody
    Background
    This gene encodes a hematopoeitin/interferon-class receptor belonging to the cytokine superfamily of receptors. The encoded gene product represents the CNTF-specific alpha subunit of a heterotrimer forming the CNTF receptor complex, which also includes LIFR and gp130. The receptor is attached to the membrane by a glycosyl-phosphatidylinositol linkage and contains an immunoglobulin-like C2-type domain and a fibronectin type-III domain. Signal transduction requires that CNTF bind first to this alpha component, which permits the recruitment of gp130 and LIFR beta to form the tripartite receptor complex. Signal transduction stimulates gene expression, cell survival or differentiation in a variety of neuronal cell types. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified.
    Alias Symbols: MGC1774
    Protein Interaction Partner: HN1L, KRTAP4-12, CLCF1, CRLF1, PLSCR1, APPBP2, IL6ST, LIFR, CNTF,
    Protein Size: 372
    Molecular Weight
    41 kDa
    Gene ID
    1271
    NCBI Accession
    NM_001842, NP_001833
    UniProt
    P26992
    Pathways
    JAK-STAT Signaling, Feeding Behaviour
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