FDPS antibody (C-Term)
Quick Overview for FDPS antibody (C-Term) (ABIN2774296)
Target
See all FDPS AntibodiesReactivity
Host
Clonality
Conjugate
Application
-
-
Binding Specificity
- C-Term
-
Sequence
- VKYKTAFYSF YLPIAAAMYM AGIDGEKEHA NAKKILLEMG EFFQIQDDYL
-
Predicted Reactivity
- Cow: 93%, Dog: 100%, Guinea Pig: 79%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 100%, Rat: 93%
-
Characteristics
- This is a rabbit polyclonal antibody against FDPS. It was validated on Western Blot.
-
Purification
- Affinity Purified
-
-
-
-
Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
-
Comment
-
Antigen size: 353 AA
-
Restrictions
- For Research Use only
-
-
-
Format
- Liquid
-
Concentration
- Lot specific
-
Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
-
Preservative
- Sodium azide
-
Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Handling Advice
- Avoid repeated freeze-thaw cycles.
-
Storage
- -20 °C
-
Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
-
-
- FDPS (Farnesyl Diphosphate Synthase (FDPS))
-
Alternative Name
- FDPS
-
Background
-
This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: FPPS, FPS
Protein Interaction Partner: UBC, SUMO2, NME1, IDH1, ADSS, NME1-NME2, STAMBP, TALDO1, SORD, PLS3, EGFR, EIF4ENIF1, ATXN1, FGFR1,
Protein Size: 353 -
Molecular Weight
- 38 kDa
-
Gene ID
- 2224
-
NCBI Accession
- NM_001135822, NP_001129294
-
UniProt
- P14324
-
Pathways
- Regulation of Muscle Cell Differentiation
Target
-