CD70 antibody (N-Term)

Catalog No. ABIN2774311

Product Details anti-CD70 Antibody

Target: CD70 (CD70 Molecule (CD70))

Binding Specificity: N-Term

Reactivity: Human, Cow, Rabbit, Horse, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD70 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: VICLVVCIQR FAQAQQQLPL ESLGWDVAEL QLNHTGPQQD PRLYWQGGPA

Predicted Reactivity: Cow: 85%, Guinea Pig: 85%, Horse: 77%, Human: 100%, Rabbit: 85%

Characteristics: This is a rabbit polyclonal antibody against CD70. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 193 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CD70

Target: CD70 (CD70 Molecule (CD70))

Alternative Name: CD70 (CD70 Products)

Background: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.
Alias Symbols: CD27L, CD27LG, TNFSF7
Protein Interaction Partner: UBC, CD27, ELAVL1,
Protein Size: 193

Molecular Weight: 21 kDa

Gene ID: 970

NCBI Accession: NM_001252, NP_001243

UniProt: P32970

Pathways: Cancer Immune Checkpoints