UACA antibody (C-Term)

Catalog No. ABIN2774333

The Rabbit Polyclonal anti-UACA antibody (ABIN2774333) specifically detects UACA in WB. The antibody is reactive with Human, Mouse, Cow, Rat, Rabbit, Dog, Guinea Pig and Horse samples.

Quick Overview for UACA antibody (C-Term) (ABIN2774333)

Target: UACA (Uveal Autoantigen With Coiled Coil Domains And Ankyrin Repeats (UACA))

Reactivity: Human, Mouse, Cow, Rat, Rabbit, Dog, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UACA antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-UACA Antibody

Binding Specificity: C-Term

Sequence: TELLNDVERL KQALNGLSQL TYTSGNPTKR QSQLIDTLQH QVKSLEQQLA

Predicted Reactivity: Cow: 100%, Dog: 85%, Guinea Pig: 86%, Horse: 86%, Human: 100%, Mouse: 85%, Rabbit: 92%, Rat: 85%

Characteristics: This is a rabbit polyclonal antibody against UACA. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1403 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for UACA

Target: UACA (Uveal Autoantigen With Coiled Coil Domains And Ankyrin Repeats (UACA))

Alternative Name: UACA

Background: UACA regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. It promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. It regulates the redistribution of APAF1 into the nucleus after proapoptotic stress and down-regulates the expression of LGALS3 by inhibiting NFKB1.
Alias Symbols: FLJ10128, KIAA1561, MGC141967, MGC141969, NUCLING
Protein Interaction Partner: KRT40, FUS, RNF2, HIF1AN, PAN2, TP63, UBC, USP48, RABEP1, STAMBP, FBXO25, NRD1, Mprip, MED14, CELSR3,
Protein Size: 1403

Molecular Weight: 154 kDa

Gene ID: 55075

NCBI Accession: NM_001008224, NP_001008225

UniProt: Q9BZF9

Pathways: Positive Regulation of Endopeptidase Activity