PDGFA antibody (C-Term)

Catalog No. ABIN2774382

The Rabbit Polyclonal anti-PDGFA antibody (ABIN2774382) specifically detects PDGFA in WB. The antibody is reactive with Human, Mouse, Rat, Dog and Guinea Pig samples.

Quick Overview for PDGFA antibody (C-Term) (ABIN2774382)

Target: PDGFA (Platelet Derived Growth Factor A (PDGFA))

Reactivity: Human, Mouse, Rat, Dog, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDGFA antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PDGFA Antibody

Binding Specificity: C-Term

Sequence: HRSVKVAKVE YVRKKPKLKE VQVRLEEHLE CACATTSLNP DYREEDTDVR

Predicted Reactivity: Dog: 85%, Guinea Pig: 82%, Human: 100%, Mouse: 85%, Rat: 85%

Characteristics: This is a rabbit polyclonal antibody against PDGFA. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human PDGFA

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PDGFA

Target: PDGFA (Platelet Derived Growth Factor A (PDGFA))

Alternative Name: PDGFA

Background: The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor beta polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have shown cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis, knockout mice die either as embryos or shortly after birth. Two splice variants have been identified for this gene.
Alias Symbols: PDGF-A, PDGF1
Protein Interaction Partner: COL6A1, COL5A1, COL4A1, COL3A1, COL2A1, COL1A2, COL1A1, PDAP1, DUSP3, SPARC, PDGFRA, PDGFA, HSPG2, FURIN, A2M, PLCG1,
Protein Size: 196

Molecular Weight: 21 kDa

Gene ID: 5154

NCBI Accession: NM_033023, NP_148983

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling