MEF2C antibody (Middle Region)

Catalog No. ABIN2774663

The Rabbit Polyclonal anti-MEF2C antibody (ABIN2774663) specifically detects MEF2C in WB. The antibody is reactive with Human, Mouse, Rat, Pig, Zebrafish (Danio rerio), Dog, Horse and Rabbit samples.

Quick Overview for MEF2C antibody (Middle Region) (ABIN2774663)

Target: MEF2C (Myocyte Enhancer Factor 2C (MEF2C))

Reactivity: Human, Mouse, Rat, Pig, Zebrafish (Danio rerio), Dog, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MEF2C antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MEF2C Antibody

Binding Specificity: Middle Region

Sequence: PPSALSQLGA CTSTHLSQSS NLSLPSTQSL NIKSEPVSPP RDRTTTPSRY

Cross-Reactivity: Dog (Canine), Chicken, Human, Mouse (Murine), Pig (Porcine), Rat (Rattus)

Predicted Reactivity: Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against MEF2C. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human MEF2C

Application Details

Application Notes: WB Suggested Anti-MEF2C Antibody Titration: 0.2-1 µg/mL
ELISA Titer: 1:1562500
Positive Control: COLO205 cell lysate.
Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 473 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MEF2C

Target: MEF2C (Myocyte Enhancer Factor 2C (MEF2C))

Alternative Name: MEF2C

Background: MEF2C is a transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. MEF2C controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. MEF2C may also be involved in neurogenesis and in the development of cortical architecture. Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.
Alias Symbols: C5DELq14.3, DEL5q14.3
Protein Interaction Partner: PLA2G12A, UBC, ASCL1, SUMO1, HDAC7, HDAC5, HDAC4, MYOD1, IFRD1, NCOA2, SIRT1, HDAC9, COPS5, YWHAZ, SPTBN1, MAPK7, EPAS1, MAPK14, VGLL2, VGLL4, TWIST2, GATA4, SOX18, EP300, SMAD2, MEF2D, MEF2C, NOTCH1, TEAD1, SP1, CCNB1, CDK1, CSNK2A1, MYOG,
Protein Size: 473

Molecular Weight: 51 kDa

Gene ID: 4208

NCBI Accession: NM_002397, NP_002388

UniProt: Q06413

Pathways: Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, BCR Signaling