FBXL3 antibody (C-Term)

Catalog No. ABIN2774688

The Rabbit Polyclonal anti-FBXL3 antibody is suitable to detect FBXL3 in samples from Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse, Rabbit, Sheep and Zebrafish (Danio rerio). It has been validated for WB.

Quick Overview for FBXL3 antibody (C-Term) (ABIN2774688)

Target: FBXL3 (F-Box and Leucine-Rich Repeat Protein 3 (FBXL3))

Reactivity: Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse, Rabbit, Sheep, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FBXL3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FBXL3 Antibody

Binding Specificity: C-Term

Purpose: Fbxl3 Antibody - C-terminal region

Sequence: ELLLALSSEK HVRLEHLRID VVSENPGQTH FHTIQKSSWD AFIKHSPKVN

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against Fbxl3. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP43099-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for FBXL3

Target: FBXL3 (F-Box and Leucine-Rich Repeat Protein 3 (FBXL3))

Alternative Name: Fbxl3

Background:

Background Information: Fbxl3 is a substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex involved in circadian clock function. The SCF(FBXL3) complex acts by mediating ubiquitination and subsequent degradation of CRY1 and CRY2. Recruiter of target protein that may recognize and bind to some phosphorylated proteins and promotes their ubiquitination and degradation.

Gene Name: F-box and leucine-rich repeat protein 3

Alternative Symbols: Ov, FBK, Fbl, Pla, Fbxl, Ovtm, Fbl3a, Fbxl3a, Play68, AU041772, AW212966

Protein Name: F-box/LRR-repeat protein 3

Molecular Weight: 49kDa

Gene ID: 50789

NCBI Accession: NP_056637

UniProt: Q8C4V4

Pathways: Photoperiodism