UBR2 antibody (C-Term)

Catalog No. ABIN2774730

The Rabbit Polyclonal anti-UBR2 antibody (ABIN2774730) specifically detects UBR2 in WB. The antibody is reactive with Human, Mouse, Rat, Horse, Cow, Dog, Rabbit, Guinea Pig and Zebrafish (Danio rerio) samples.

Quick Overview for UBR2 antibody (C-Term) (ABIN2774730)

Target: UBR2 (Ubiquitin Protein Ligase E3 Component N-Recognin 2 (UBR2))

Reactivity: Human, Mouse, Rat, Horse, Cow, Dog, Rabbit, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UBR2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-UBR2 Antibody

Binding Specificity: C-Term

Purpose: UBR2 Antibody - C-terminal region

Sequence: QGLRRGNPLH LCKERFKKIQ KLWHQHSVTE EIGHAQEANQ TLVGIDWQHL

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 93%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against UBR2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human UBR2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP43188-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for UBR2

Target: UBR2 (Ubiquitin Protein Ligase E3 Component N-Recognin 2 (UBR2))

Alternative Name: UBR2

Background:

Background Information: Proteolysis by the ubiquitin-proteasome system controls the concentration of many regulatory proteins. The selectivity of ubiquitylation is determined by ubiquitin E3 ligases, which recognize the substrate's destabilization signal, or degron. The E3 ligase UBR2 participates in the N-end rule pathway, which targets proteins bearing an N-terminal degron, or N-degron.Proteolysis by the ubiquitin-proteasome system controls the concentration of many regulatory proteins. The selectivity of ubiquitylation is determined by ubiquitin E3 ligases, which recognize the substrate's destabilization signal, or degron. The E3 ligase UBR2 participates in the N-end rule pathway, which targets proteins bearing an N-terminal degron, or N-degron (Kwon et al., 2003 [PubMed 14585983]).[supplied by OMIM].

Gene Name: Ubiquitin protein ligase E3 component n-recognin 2

Alternative Symbols: C6orf133, bA49A4.1, dJ242G1.1, dJ392M17.3

Protein Name: E3 ubiquitin-protein ligase UBR2

Molecular Weight: 200kDa

Gene ID: 23304

NCBI Accession: NP_056070

UniProt: Q8IWV8