GJC2 antibody (Middle Region)

Catalog No. ABIN2774865

Product Details anti-GJC2 Antibody

Target: GJC2 (Gap Junction Protein, gamma 2, 47kDa (GJC2))

Binding Specificity: Middle Region

Reactivity: Human, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GJC2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: APASRTGSAT SAGTVGEQGR PGTHERPGAK PRAGSEKGSA SSRDGKTTVW

Predicted Reactivity: Human: 100%, Rabbit: 100%

Characteristics: This is a rabbit polyclonal antibody against GJC2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human GJC2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 439 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for GJC2

Target: GJC2 (Gap Junction Protein, gamma 2, 47kDa (GJC2))

Alternative Name: GJC2 (GJC2 Products)

Synonyms: GJA12 antibody, cx47 antibody, gja12 antibody, cx46.6 antibody, pmldar antibody, MGC146420 antibody, B230382L12Rik antibody, Cx47 antibody, Gja12 antibody, CX46.6 antibody, HLD2 antibody, LMPH1C antibody, PMLDAR antibody, SPG44 antibody, gap junction protein gamma 2 antibody, si:dkey-91f15.1 antibody, gap junction protein, gamma 2 antibody, GJC2 antibody, gjc2 antibody, si:dkey-91f15.1 antibody, Gjc2 antibody

Background: GJC2 is a gap junction protein. Gap junction proteins are members of a large family of homologous connexins and comprise 4 transmembrane, 2 extracellular, and 3 cytoplasmic domains. This gene plays a key role in central myelination and is involved in peripheral myelination in humans. Defects in this gene are the cause of autosomal recessive Pelizaeus-Merzbacher-like disease-1.This gene encodes a gap junction protein. Gap junction proteins are members of a large family of homologous connexins and comprise 4 transmembrane, 2 extracellular, and 3 cytoplasmic domains. This gene plays a key role in central myelination and is involved in peripheral myelination in humans. Defects in this gene are the cause of autosomal recessive Pelizaeus-Merzbacher-like disease-1.
Alias Symbols: CX46.6, Cx47, GJA12, MGC105119, PMLDAR, HLD2, SPG44, LMPH1C
Protein Interaction Partner: ALB,
Protein Size: 439

Molecular Weight: 47 kDa

Gene ID: 57165

NCBI Accession: NM_020435, NP_065168

UniProt: Q5T442