THO Complex 4 antibody (N-Term)

Catalog No. ABIN2774915

Cited in 2+ publications. The Rabbit Polyclonal anti-THO Complex 4 antibody (ABIN2774915) specifically detects THO Complex 4 in WB and IHC. The antibody is reactive with Human, Mouse, Rat, Cow, Zebrafish (Danio rerio) and Dog samples.

Quick Overview for THO Complex 4 antibody (N-Term) (ABIN2774915)

Target: THO Complex 4 (THOC4)

Reactivity: Human, Mouse, Rat, Cow, Zebrafish (Danio rerio), Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This THO Complex 4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-THO Complex 4 Antibody

Binding Specificity: N-Term

Purpose: THOC4 Antibody - N-terminal region

Sequence: GGGPIRNRPA IARGAAGGGG RNRPAPYSRP KQLPDKWQHD LFDSGFGGGA

Predicted Reactivity: Cow: 100%, Dog: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against THOC4. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human THOC4

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP43055-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-THO Complex 4 antibody (ABIN2774915)

Ding, Enriquez-Algeciras, Dave, Perez-Pinzon, Bhattacharya: "The role of deimination in ATP5b mRNA transport in a transgenic mouse model of multiple sclerosis." in: EMBO reports, Vol. 13, Issue 3, pp. 230-6, (2012) (PubMed).

Strässer, Masuda, Mason, Pfannstiel, Oppizzi, Rodriguez-Navarro, Rondón, Aguilera, Struhl, Reed, Hurt: "TREX is a conserved complex coupling transcription with messenger RNA export." in: Nature, Vol. 417, Issue 6886, pp. 304-8, (2002) (PubMed).

Target Details for THO Complex 4

Target: THO Complex 4 (THOC4)

Alternative Name: THOC4

Background:

Targeted Subunit: 4

Background Information: THOC4 is a heat stable, nuclear protein and functions as a molecular chaperone. It is thought to regulate dimerization, DNA binding, and transcriptional activity of basic region-leucine zipper (bZIP) proteins.The protein encoded by this gene is a heat stable, nuclear protein and functions as a molecular chaperone. It is thought to regulate dimerization, DNA binding, and transcriptional activity of basic region-leucine zipper (bZIP) proteins.

Gene Name: Aly/REF export factor

Alternative Symbols: ALY, BEF, REF, THOC4, ALY/REF

Protein Name: THO complex subunit 4

Molecular Weight: 28kDa

Gene ID: 10189

NCBI Accession: NP_005773

UniProt: Q86V81