Axin antibody (N-Term)
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- Target See all Axin (AXIN1) Antibodies
- Axin (AXIN1) (Axin 1 (AXIN1))
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Binding Specificity
- N-Term
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Axin antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- TVGRDQALGA RQAERPWPPH SHPSTPEPSV RNDGKRRFMG VRRQGSRGAG
- Characteristics
- This is a rabbit polyclonal antibody against Axin1. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N-terminal region of Mouse Axin1
- Top Product
- Discover our top product AXIN1 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 993 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- Axin (AXIN1) (Axin 1 (AXIN1))
- Alternative Name
- Axin1 (AXIN1 Products)
- Synonyms
- AXIN1 antibody, axin antibody, fused antibody, xAxin antibody, LOC100226467 antibody, AXIN antibody, PPP1R49 antibody, AI316800 antibody, Axin antibody, Fu antibody, Kb antibody, Ki antibody, kinky antibody, knobbly antibody, AXIN1-RGS antibody, wu:fi22e03 antibody, wu:fj14c08 antibody, wu:fk11b03 antibody, zgc:109872 antibody, axin 1 antibody, axin 1 S homeolog antibody, axin 1 L homeolog antibody, AXIN1 antibody, axin1.S antibody, axin1.L antibody, Axin1 antibody, axin1 antibody
- Background
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Axin1 is a component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Axin1 controls dorsoventral patterning via two opposing effects, down-regulates beta-catenin to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. It also facilitates the phosphorylation of APC by GSK3B, facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation and enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7.
Alias Symbols: AI316800, Axin, Fu, Kb, Ki, fused, kinky, knobbly
Protein Interaction Partner: Lrp5, Gsk3b, Prmt1, Ctnnb1, GSK3A, Trp53, Hipk2, Nck2, Lrrk2, ITCH, WWP1, MAP3K1, Kif3a, Cops2, Dvl2, Axin1, Apc, Dixdc1, Ppp2r1a, Map3k4, Ppp2ca, Rnf111, Rnf11, Smad7, Smad6, Smad3, Dvl1, Cdh2, APC2,
Protein Size: 993 - Molecular Weight
- 110 kDa
- Gene ID
- 12005
- NCBI Accession
- XM_914907, XP_920000
- UniProt
- O70239
- Pathways
- WNT Signaling, Sensory Perception of Sound, Regulation of G-Protein Coupled Receptor Protein Signaling
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