GABRB1 antibody (N-Term)

Catalog No. ABIN2776114

The Rabbit Polyclonal anti-GABRB1 antibody is suitable to detect GABRB1 in samples from Human, Rat, Mouse, Cow, Horse, Rabbit, Dog, Guinea Pig, Zebrafish (Danio rerio) and Sheep. It has been validated for WB.

Quick Overview for GABRB1 antibody (N-Term) (ABIN2776114)

Target: GABRB1 (gamma-aminobutyric Acid (GABA) A Receptor, Subunit beta 1 (GABRB1))

Reactivity: Human, Rat, Mouse, Cow, Horse, Rabbit, Dog, Guinea Pig, Zebrafish (Danio rerio), Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GABRB1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GABRB1 Antibody

Binding Specificity: N-Term

Purpose: GABRB1 Antibody - N-terminal region

Sequence: TLDNRVADQL WVPDTYFLND KKSFVHGVTV KNRMIRLHPD GTVLYGLRIT

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against GABRB1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human GABRB1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP34986-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for GABRB1

Target: GABRB1 (gamma-aminobutyric Acid (GABA) A Receptor, Subunit beta 1 (GABRB1))

Alternative Name: GABRB1

Background:

Targeted Subunit: beta-1

Background Information: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster comprised of genes encoding alpha 4, alpha 2 and gamma 1 subunits of the GABA A receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Gamma-aminobutyric acid (GABA) A receptor, beta 1

Alternative Symbols: DEE45, EIEE45

Protein Name: Gamma-aminobutyric acid receptor subunit beta-1

Molecular Weight: 51kDa

Gene ID: 2560

NCBI Accession: NP_000803

UniProt: P18505