CLCNKA antibody (N-Term)

Catalog No. ABIN2776159

The Rabbit Polyclonal anti-CLCNKA antibody (ABIN2776159) specifically detects CLCNKA in WB. The antibody is reactive with Human, Mouse, Rat, Cow and Pig samples.

Quick Overview for CLCNKA antibody (N-Term) (ABIN2776159)

Target: CLCNKA (Chloride Channel Ka (CLCNKA))

Reactivity: Human, Mouse, Rat, Cow, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CLCNKA antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CLCNKA Antibody

Binding Specificity: N-Term

Purpose: CLCNKA Antibody - N-terminal region

Sequence: MEELVGLREG FSGDPVTLQE LWGPCPHIRR AIQGGLEWLK QKVFRLGEDW

Predicted Reactivity: Cow: 90%, Human: 100%, Mouse: 85%, Pig: 85%, Rat: 85%

Characteristics: This is a rabbit polyclonal antibody against CLCNKA. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CLCNKA

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8096916

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for CLCNKA

Target: CLCNKA (Chloride Channel Ka (CLCNKA))

Alternative Name: CLCNKA

Background:

Background Information: CLCNKA is a member of the CLC family of voltage-gated chloride channels. It is predicted to have 12 transmembrane domains, and requires a beta subunit called barttin to form a functional channel. It is thought to function in salt reabsorption in the kidney and potassium recycling in the inner ear. This gene is a member of the CLC family of voltage-gated chloride channels. The encoded protein is predicted to have 12 transmembrane domains, and requires a beta subunit called barttin to form a functional channel. It is thought to function in salt reabsorption in the kidney and potassium recycling in the inner ear. The gene is highly similar to CLCNKB, which is located 10 kb downstream from this gene. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Name: Chloride channel, voltage-sensitive Ka

Alternative Symbols: CLCK1, ClC-K1, hClC-Ka

Protein Name: Chloride channel protein ClC-Ka

Molecular Weight: 75kDa

Gene ID: 1187

NCBI Accession: NP_004061

UniProt: P51800

Pathways: Response to Water Deprivation