TRPC6 antibody (Middle Region)

Catalog No. ABIN2776163

The Rabbit Polyclonal anti-TRPC6 antibody is suitable to detect TRPC6 in samples from Human, Mouse, Rat, Horse, Pig, Cow, Dog, Guinea Pig and Saccharomyces cerevisiae. It has been validated for WB.

Quick Overview for TRPC6 antibody (Middle Region) (ABIN2776163)

Target: TRPC6 (Transient Receptor Potential Cation Channel, Subfamily C, Member 6 (TRPC6))

Reactivity: Human, Mouse, Rat, Horse, Pig, Cow, Dog, Guinea Pig, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRPC6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TRPC6 Antibody

Binding Specificity: Middle Region

Sequence: KKGFQEDAEM NKINEEKKLG ILGSHEDLSK LSLDKKQVGH NKQPSIRSSE

Predicted Reactivity: Cow: 92%, Dog: 92%, Guinea Pig: 92%, Horse: 92%, Human: 100%, Mouse: 85%, Pig: 100%, Rat: 77%, Yeast: 86%

Characteristics: This is a rabbit polyclonal antibody against TRPC6. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TRPC6

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 931 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TRPC6

Target: TRPC6 (Transient Receptor Potential Cation Channel, Subfamily C, Member 6 (TRPC6))

Alternative Name: TRPC6

Background: TRPC6 forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2).
Alias Symbols: FLJ11098, FLJ14863, FSGS2, TRP6
Protein Interaction Partner: RNF24, TRPC3, ORAI1, TRPM2, TRPC6, SRC, ITPR3, MX1, FYN, TRPC7, TRPC5, TRPC4, TRPC1, TRPC2, ITPR1,
Protein Size: 931

Molecular Weight: 106 kDa

Gene ID: 7225

NCBI Accession: NM_004621, NP_004612

UniProt: Q9Y210